Evaluating fluid responsiveness in ICU patients with acute respiratory failure
Pronostic Value of Fluid Responsiveness, Evaluated by Inferior Vena Cava Collapsibility Index, in Patients Admitted in ICU With Acute Respiratory Failure '' PRIVACY Study''
This study is testing if measuring a specific part of the heart's blood flow can help doctors decide how much fluid to give ICU patients with breathing problems to avoid complications.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Trial ID | NCT06286306 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the prognostic value of the inferior vena cava collapsibility index (cIVC) in patients admitted to the ICU with acute respiratory failure. By recording video loops of the inferior vena cava during transthoracic echocardiography, the study will measure the cIVC to determine preload responsiveness in spontaneously breathing patients. The findings could help guide fluid management and reduce the risk of fluid overload and invasive mechanical ventilation. The study will analyze data from patients who meet specific inclusion criteria and will be conducted at a single hospital in Lille, France.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old with hypoxemic acute respiratory failure requiring oxygen support and undergoing echocardiography.
Not a fit: Patients who are pregnant, have severe disabilities, or are in a moribund state may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve fluid management strategies in ICU patients, potentially reducing mortality rates associated with acute respiratory failure.
How similar studies have performed: Previous research has indicated the potential utility of the cIVC in assessing preload responsiveness, suggesting that this approach may be promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Age \> 18 years Registered in the French National Health Insurance system Presenting all the following criteria: * Admission in ICU for less than 48 hours * Type 1 acute respiratory failure: hypoxemia (PaO2\< 60 mmHg on room air) without hypercapnia (PaCO2 \< 45 mmHg) * Requiring oxygen support of ≥ 5L./min * Necessitating transthoracic echocardiography for diagnostic purposes Exclusion Criteria: Pregnancy Adult with disability or without social protection BMI \> 35 kg/m² Withhold decision regarding invasive mechanical ventilation Moribund state diagnosed as a SOFA score \> 20
Where this trial is running
Lille
- Hopital Roger Salengro — Lille, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.