Evaluating FKBP51s protein levels in glioblastoma patients before and after surgery
FKBP51s: a New Molecular Biomarker for Glioblastoma? Pre- and Post-operative Blood Levels Evaluation of FKBP51s Protein and Correlation With MRI Phenotype
This study is testing if measuring a specific protein in the blood of glioblastoma patients before and after surgery can help us understand their tumor better and how it might respond to treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma) |
| Trial ID | NCT05793021 on ClinicalTrials.gov |
What this trial studies
This interventional study aims to explore the relationship between FKBP51s protein levels in blood and MRI phenotypes in adult patients diagnosed with glioblastoma. Participants will undergo blood sampling to measure FKBP51s levels both before and after surgical intervention. The study seeks to establish whether these protein levels correlate with the imaging characteristics observed in MRI scans, potentially providing insights into glioblastoma behavior and treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 years and older with a confirmed diagnosis of glioblastoma who are scheduled for surgery.
Not a fit: Patients without confirmed histological diagnosis of glioblastoma or those lacking necessary radiological documentation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to a new biomarker for monitoring glioblastoma progression and response to treatment.
How similar studies have performed: While the specific approach of correlating FKBP51s protein levels with MRI phenotypes is novel, similar studies have explored biomarkers in glioblastoma with varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>= 18 years * Diagnosis of Glioblastoma with surgery criteria * Brain MRI with contrast both pre and post surgery Exclusion Criteria: * No availability of radiological documentation * Glioblastoma diagnosis not confirmed by Histological examination * Withdrawal of ICF
Where this trial is running
Roma
- Fondazione Policlinico Universitaro "A. Gemelli" IRCCS — Roma, Italy (Recruiting)
Study contacts
- Study coordinator: Simona Gaudino, MD
- Email: simona.gaudino@policlinicogemelli.it
- Phone: 0630155464
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.