Evaluating fast-rotation CT for aortic stenosis workup
Impact of Fast Gantry Rotation Cardiac CT Angiography on Coronary Motion Artifacts in the Absence of β-Blocker Premedication in Patients Undergoing Aortic Stenosis Workup: a Single-centre Randomized Controlled Trial
This study is testing if a new faster CT scan can help doctors get clearer images of the heart in patients with aortic stenosis without needing to control their heart rate.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 124 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University of Lausanne Hospitals Academic / other |
| Locations | 1 site (Lausanne) |
| Trial ID | NCT05709652 on ClinicalTrials.gov |
What this trial studies
This study evaluates the clinical value of a novel CT gantry with a 0.23 second rotation time compared to a 0.28 second rotation time in patients undergoing aortic CT angiography for aortic stenosis. Patients will be randomly assigned to receive either the faster or standard rotation time, and the interpretability of coronary arteries will be assessed in both groups. The study aims to enhance the accuracy of cardiac CT without the need for heart rate control, thereby improving patient management during aortic valve assessments.
Who should consider this trial
Good fit: Ideal candidates are patients undergoing cardiac CT due to known or suspected aortic valve stenosis.
Not a fit: Patients who are unable to hold their breath, have severe renal impairment, or are in critical medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and safer diagnostic imaging for patients with aortic stenosis.
How similar studies have performed: Other studies have shown promising results with faster CT rotation speeds, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Subjected to cardiac CT due to known or suspected aortic valve stenosis Exclusion Criteria: * Patients unable to hold their breath, deaf or visually impaired * Estimated glomerular filtration rate (eGFR) of \<30 mL/min * Hemodynamic instability or cardiogenic shock, Acute pulmonary edema, Exacerbated chronic obstructive pulmonary disease, Pregnant and breast-feeding women * Patients with prior coronary artery bypass grafting (CABG) * Patient incapable of discernment
Where this trial is running
Lausanne
- Lausanne University Hospital (CHUV) — Lausanne, Switzerland (Recruiting)
Study contacts
- Principal investigator: David C. Rotzinger, MD, PhD — Chuv
- Study coordinator: David C Rotzinger, MD, PhD
- Email: david.rotzinger@chuv.ch
- Phone: 021 314 44 75
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.