Evaluating embryo testing for chromosomal abnormalities
Official title: Assessment if Predictive Values of Preimplantation Genetic Testing for Aneuploidy (PGT.A). A Prospective, Blinded, Prognostic Cohort Study With the Aim of Determining if Preimplantation Genetic Testing for Aneuploidy Can be Used to Predict Clinical Outcomes.
Run by Aalborg University Hospital · NCT06915311 · Data updated 2026-11-12
This study is testing if a new method of checking embryos for genetic problems can help couples using fertility treatments have healthier babies and reduce the chances of miscarriage.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | Aalborg University Hospital Academic / other |
| Locations | 1 site (Aalborg) |
| Status | Recruiting |
| Started | April 22, 2025 |
| Main results expected | May 1, 2028 |
| Study ends | May 1, 2030 |
| Registry record updated | April 25, 2025 |
| Trial ID | NCT06915311 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals or couples undergoing preimplantation genetic testing for monogenic disorders.
✕Probably not a fit
Patients who are not undergoing preimplantation genetic testing or those with no interest in assisted reproductive technology may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the effectiveness of preimplantation genetic testing for aneuploidy (PGT-A) in selecting embryos free from chromosomal abnormalities. By analyzing DNA from biopsies or spent culture media of embryos created through assisted reproductive technology, the study seeks to identify embryos that are less likely to result in miscarriage or birth defects. The goal is to enhance the chances of healthy live births while minimizing the emotional and financial burdens associated with fertility treatments.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of miscarriage and increase the likelihood of healthy pregnancies for patients undergoing fertility treatments.
How similar studies have gone: Previous studies have shown promise in using preimplantation genetic testing for aneuploidy, indicating that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing preimplantation genetic testing for monogenic disorders (PGT-M) Exclusion Criteria: * None
Where it's running
-
Center for Preimplantation Genetic Testing, Aalborg University Hospital
Aalborg, Denmark Recruiting
Study contacts
- Study coordinator: Christian L.F. Toft, Molecular Biologist, Ph.D.
- Email: PGT-forskning@rn.dk
- Phone: +4530631423
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Non-invasive fetal cell test to check fetal chromosomal status in early pregnancy
A large, non-invasive blood test in pregnant people between 10 and 20 weeks looks for fetal cells in the mother's blood to see if the baby has certain chromosomal conditions, comparing results to invasive or postnatal diagnoses.
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Tracking outcomes after transferring embryos with non-euploid PGT-A results
This registry collects pregnancy and child health information from people using IVF who plan to transfer embryos with non-euploid PGT-A results to see what the outcomes are.
-
Comparing two methods for sperm preparation in IVF
This study is testing which of two sperm preparation methods helps improve the chances of having healthy embryos for couples undergoing IVF.
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Outcomes of transferring embryos identified as abnormal
This study is testing whether transferring embryos that are found to have genetic abnormalities can lead to successful pregnancies and healthy children for patients who have no other viable embryo options.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.