Evaluating embryo testing for chromosomal abnormalities
Assessment if Predictive Values of Preimplantation Genetic Testing for Aneuploidy (PGT.A). A Prospective, Blinded, Prognostic Cohort Study With the Aim of Determining if Preimplantation Genetic Testing for Aneuploidy Can be Used to Predict Clinical Outcomes.
This study is testing if a new method of checking embryos for genetic problems can help couples using fertility treatments have healthier babies and reduce the chances of miscarriage.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 220 (estimated) |
| Sex | All |
| Sponsor | Aalborg University Hospital Academic / other |
| Locations | 1 site (Aalborg) |
| Trial ID | NCT06915311 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the effectiveness of preimplantation genetic testing for aneuploidy (PGT-A) in selecting embryos free from chromosomal abnormalities. By analyzing DNA from biopsies or spent culture media of embryos created through assisted reproductive technology, the study seeks to identify embryos that are less likely to result in miscarriage or birth defects. The goal is to enhance the chances of healthy live births while minimizing the emotional and financial burdens associated with fertility treatments.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals or couples undergoing preimplantation genetic testing for monogenic disorders.
Not a fit: Patients who are not undergoing preimplantation genetic testing or those with no interest in assisted reproductive technology may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of miscarriage and increase the likelihood of healthy pregnancies for patients undergoing fertility treatments.
How similar studies have performed: Previous studies have shown promise in using preimplantation genetic testing for aneuploidy, indicating that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing preimplantation genetic testing for monogenic disorders (PGT-M) Exclusion Criteria: * None
Where this trial is running
Aalborg
- Center for Preimplantation Genetic Testing, Aalborg University Hospital — Aalborg, Denmark (Recruiting)
Study contacts
- Study coordinator: Christian L.F. Toft, Molecular Biologist, Ph.D.
- Email: PGT-forskning@rn.dk
- Phone: +4530631423
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.