Clinical trial Recruiting at 1 site Observational Ages 18 to 90

Evaluating early inflammatory polyarthritis for better treatment outcomes

Official title: Early Prediction of Patient-related and Radiological Outcomes in Patients With Recent-onset Inflammatory Polyarthritis (EPA) Using Established and Novel Independent Predictors

Run by Université de Sherbrooke · NCT00512239 · Data updated 2026-11-12

This study is trying to find out if certain blood markers can help doctors identify early on which patients with inflammatory polyarthritis, especially rheumatoid arthritis, might need stronger treatment to avoid severe disease.

Quick facts

Study typeObservational
Ages18 Years to 90 Years
SexAll
Enrollment1000 (estimated)
SponsorUniversité de Sherbrooke
Academic / other
Locations1 site (Sherbrooke, Quebec)
StatusRecruiting
StartedJuly 1998
Main results expectedDecember 2030
Study endsDecember 2035
Registry record updatedMarch 25, 2025
Trial IDNCT00512239 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with early rheumatoid arthritis or early inflammatory arthritis.

Probably not a fit

Patients with infectious arthritis or microcrystalline arthritis will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the prognostic markers in patients with early inflammatory polyarthritis, particularly focusing on rheumatoid arthritis. It seeks to identify which patients are likely to experience persistent and severe disease based on the presence of specific autoantibodies, such as anti-Sa and anti-CCP antibodies. By evaluating these markers over a period of 60 months, the study intends to improve treatment strategies by determining who should receive aggressive therapy early in their disease course. The study is conducted at the Centre hospitalier universitaire de Sherbrooke in Quebec, Canada.

Why it matters

Potential benefit: If successful, this study could lead to more targeted and effective treatment strategies for patients with early inflammatory arthritis, potentially reducing long-term disability.

How similar studies have gone: Other studies have shown promise in using biomarkers for risk stratification in rheumatoid arthritis, suggesting that this approach may yield valuable insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Early Rheumatoid arthritis
* Early Inflammatory Arthritis

Exclusion Criteria:

* Refusal or inability to consent
* Infectious arthritis
* Microcrystalline arthritis

Where it's running

  • Centre hospitalier universitaire de Sherbrooke
    Sherbrooke, Quebec, Canada
    Recruiting

Study contacts

  • Principal investigator: Gilles Boire, MD, MSc — Centre de recherche du Centre hospitalier universitaire de Sherbrooke
  • Study coordinator: Gilles Boire, MD, MSc
  • Email: Gilles.Boire@USherbrooke.ca
  • Phone: (819) 564-5261

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  • PTC844 in people with active rheumatoid arthritis

    This study tests whether PTC844 is safe and how it behaves in the body compared with placebo for people with active rheumatoid arthritis.

    Recruiting at 6 sites Phase 2 PTC Therapeutics · Chandler, Arizona and 25 other locations · NCT07779616

  • First-in-human test of CND319 in healthy people and people with rheumatic diseases

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    Recruiting Phase 1 Candid Therapeutics · Melbourne, Victoria · NCT07712939

  • IV sarilumab for adults with rheumatoid arthritis

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    Recruiting at 12 sites Phase 1/2 Sanofi · Centennial, Colorado and 11 other locations · NCT07704580

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.