Evaluating doxycycline for treating Thyroid Associated Ophthalmopathy
A Multi-model Image to Evaluate the Efficacy of Doxycycline in Thyroid Associated Ophthalmopathy
This study is testing if doxycycline can help people with Thyroid Associated Ophthalmopathy feel better and improve their eye symptoms.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT05112211 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of doxycycline in treating Thyroid Associated Ophthalmopathy (TAO) using multi-modal imaging techniques. TAO is an autoimmune condition that leads to the enlargement of extraocular muscles and increased orbital fat, affecting visual function and appearance. The study aims to provide more accurate measurements of treatment outcomes compared to traditional subjective methods. Participants will be monitored for changes in symptoms and imaging results over the course of the treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 diagnosed with Thyroid Associated Ophthalmopathy.
Not a fit: Patients with sight-threatening TAO or those who are allergic to tetracycline may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new effective treatment option for patients suffering from Thyroid Associated Ophthalmopathy.
How similar studies have performed: While the use of doxycycline in this context is relatively novel, similar studies have shown promising results in treating other autoimmune conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed consent * Age 18-70 years old * Diagnosed with TAO Exclusion Criteria: * Sight-threatening TAO with dysthyroid optic neuropathy * Allergy of tetracycline * Have contraindications of MRI(metal pacemaker, fake teeth, foreign body and other materials which will disturb the examination)
Where this trial is running
Guangzhou, Guangdong
- Zhongshan Ophthalmic Center — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Principal investigator: Dan Liang — Zhongshan Ophthalmic Center, Sun Yat-sen University
- Study coordinator: Dan Liang
- Email: liangdan@gzzoc.com
- Phone: （86）-87330402
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.