Evaluating DIC Scores and Organ Dysfunction in Septic Shock Patients

Effect of Disseminated Intravascular Coagulation (DIC) Score Changes on Organ Dysfunction in Septic Shock Patients

This study is trying to see how DIC scores relate to organ problems in adults with septic shock who are in the ICU and need medication to support their blood pressure.

Quick facts

• Study type: Observational
• Enrollment: 60 (estimated)
• Ages: 18 Years to 65 Years
• Sex: All
• Sponsor: Sanjay Gandhi Postgraduate Institute of Medical Sciences (other gov)
• Locations: 1 site (Lucknow, Uttar Pradesh)
• Trial ID: NCT06363149 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the relationship between disseminated intravascular coagulation (DIC) scores and organ dysfunction in patients experiencing septic shock. It focuses on adult ICU patients who require vasopressors for septic shock, monitoring how DIC may influence the severity of organ dysfunction. The study seeks to provide insights into the progression of DIC in septic shock cases, which is particularly prevalent in low and medium-income countries. By understanding these dynamics, the research hopes to improve prognostication and guide early interventions for affected patients.

Who should consider this trial

Good fit: Ideal candidates for this study are adult ICU patients aged 18 to 65 who are experiencing septic shock and require vasopressors.

Not a fit: Patients with septic shock lasting less than 12 hours or more than 24 hours, those under 18 or over 65, or those with an expected survival of less than 72 hours may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance early detection and management of organ dysfunction in septic shock patients, potentially reducing mortality rates.

How similar studies have performed: While the specific approach of this study may be novel, existing literature indicates a significant prevalence of DIC in septic shock patients, suggesting a need for further exploration in this area.

Eligibility criteria

Inclusion Criteria:

* Adult ICU patients having septic shock as defined by Sepsis -3 definition requiring vasopressor for at least 12 hours duration will be considered.

Exclusion Criteria:

* Patient having septic shock duration either less than 12 hours or more than 24 hours at the time of the inclusion
* Age less than 18 years or more than 65 years
* Expected survival less than 72 hours
* Caregiver refused for the consent to participate in the study

Where this trial is running

Lucknow, Uttar Pradesh

• Sanjay Gandhi Postgraduate Institute of Medical Sciences — Lucknow, Uttar Pradesh, India (RECRUITING)

Study contacts

• Principal investigator: Mohan Gurjar, MD, PDCC — Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)
• Study coordinator: Mohan Gurjar, MD, PDCC

Conditions: Septic Shock, Disseminated Intravascular Coagulation, Critical Illnesses, Multiple Organ Dysfunction Syndrome