Evaluating coronary artery plaque using advanced imaging techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to analyze coronary artery plaque characteristics and local hemodynamic parameters in patients with chronic coronary syndrome or non-ST-segment elevation acute coronary syndrome. It utilizes multimodality imaging, including noninvasive coronary CT angiography and intracoronary imaging techniques like intravascular ultrasound and optical coherence tomography. The study seeks to enhance plaque analysis accuracy by integrating these imaging modalities and developing a new high-risk plaque model based on the findings. Patients will be followed for two years to assess the model's effectiveness in predicting major adverse cardiovascular events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Patients with CCS or NSTE-ACS
* Receive CCTA scan, with marginal lesions (DS between 40%-69%) or obstructive lesions (DS ≥70% or CT-FFR \<0.8) in major coronary arteries
* Receive invasive coronary angiography and intracoronary imaging examination, including IVUS, OCT, NIRS, within 1 month after CCTA

Exclusion Criteria:

* Unsuitable for CCTA (such as severe renal impairment, uncontrolled thyroid condition, allergic to iodine, etc.)
* Receive percutaneous coronary intervention (PCI) within 6 months
* Prior history of myocardial infarction or heart failure
* Prior history of coronary artery bypass graft (CABG)
* Abnormal liver function (serum alanine aminotransferase \[ALT\] level exceeding 3 times the upper limit of normal) or abnormal kidney function (eGFR ≤30%)
* Familial hypercholesterolemia
* Estimated survival ≤ 1 year
* Malignant tumor
* Pregnant or lactation, or have the intention to give birth within one year
* Poor compliance, unable to follow-up

Where it's running

• Ruijin Hospital, Shanghai Jiaotong University School of Medicine
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Study coordinator: Xiaoqun Wang, M.D., Ph.D.
• Email: xiaoqun_wang@hotmail.com
• Phone: +86 21 64370045

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.