Evaluating changes in swallowing, taste, and smell in stroke patients
Changes in Sensitivity of Swallowing-relevant Structures, Taste and Smell in Stroke Patients
This study looks at how swallowing, taste, and smell change in stroke patients, especially those who have trouble swallowing, to see if there are any links between these issues.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Giessen Academic / other |
| Locations | 1 site (Giessen, Hesse) |
| Trial ID | NCT03240965 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the changes in swallowing, taste, and smell in stroke patients, particularly focusing on those with dysphagia. It employs flexible endoscopic evaluation of swallowing (FEES) and sensitivity threshold tests to assess the swallowing reflex and pharyngeal sensitivity. Additionally, neuropsychological testing will be conducted to evaluate any cognitive deficits related to swallowing. The study also aims to explore the correlation between changes in taste and smell in stroke patients, an area that has not been systematically researched.
Who should consider this trial
Good fit: Ideal candidates include stroke patients who have experienced a new supratentorial stroke within the last 72 hours and can provide informed consent.
Not a fit: Patients with pre-existing strokes or dysphagia, extensive white matter lesions, or allergies to odorous substances may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of dysphagia in stroke patients, potentially reducing the risk of aspiration pneumonia.
How similar studies have performed: While there have been studies on swallowing and sensitivity in stroke patients, this specific combination of assessments is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Volunteers: * informed consent Stroke patients: * informed consent * new supratentorial stroke (\<72 hours old) confirmed by CT (computed tomography) or MRI (magnetic resonance imaging) Exclusion Criteria: * pre-existing stroke oder dysphagia * extensive white matter lesions in CT- or MRI-scan * allergies to odorous substances or flavoring * contraindications for FEES (flexible endoscopic evaluation of swallowing), CT or MRI (stroke patients only)
Where this trial is running
Giessen, Hesse
- Universitätsklinikum Gießen — Giessen, Hesse, Germany (Recruiting)
Study contacts
- Principal investigator: Tobias Braun, M.D. — University Giessen
- Study coordinator: Tobias Braun, M.D.
- Email: tobias.braun@neuro.med.uni-giessen.de
- Phone: +49(0)-641-985
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.