Evaluating changes in MR imaging and biological parameters during radiotherapy for cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The MR-BIO study investigates how tumors and normal tissues change during radiotherapy by utilizing high-resolution MR imaging from an MR Linear accelerator. Participants receiving standard care at The Christie NHS Foundation Trust will provide weekly blood and urine samples throughout their treatment. The study aims to correlate these imaging and biological changes with clinical outcomes, enhancing the precision of cancer treatment. This observational study includes all patients treated with the MR Linac, regardless of tumor site.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Be willing and able to provide written consent. Over 18 years of age. Undergo and satisfy MRI Safety Screening Patient volunteers must be under the care of a clinical oncologist at The Christie NHS Foundation Trust and be planned to receive radiotherapy to the target site to be imaged.

Patient volunteers must be able to give blood and/or urine sample as required through the treatment period.

Non-patient (healthy) volunteers must have no known or suspected significant medical condition.

Exclusion Criteria:

The following apply to both patients and healthy volunteers:

Any conditions that would be a contra-indication to MRI including:

* Failure to satisfy MRI Safety Screening Form
* Implanted pacemakers and/or pacing wires
* Cochlear implants
* Programmable hydrocephalus shunts
* Ferromagnetic implants
* Unable to tolerate MR scans
* Known HIV or active HepB or C
* Pregnancy Healthy volunteers must not be a member of the study team.

Where it's running

• The Christie NHS Foundation Trust
  Manchester, United Kingdom Recruiting

Study contacts

• Principal investigator: Ananya Choudhury, PhD, FRCR, MRCP, MA, MB BChir, — The Christie NHS Foundation Trust
• Study coordinator: Rachel Reed, MSc
• Email: rachel.reed18@nhs.net
• Phone: 01619187029

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.