Evaluating Cascade Screening for High Lipoprotein(a) Levels
Evaluation of Cascade Screening for Elevated Lipoprotein(a) in Relatives to Patients With Atherosclerotic Coronary Artery Disease
Karolinska Institutet · NCT06157983
This study is testing if screening family members of patients with high lipoprotein(a) levels can help find others at risk for heart disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1950 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Karolinska Institutet (other) |
| Locations | 1 site (Stockholm) |
| Trial ID | NCT06157983 on ClinicalTrials.gov |
What this trial studies
This project aims to assess how elevated levels of lipoprotein(a) in patients with atherosclerotic coronary artery disease affect their first- and second-degree relatives. By utilizing cascade screening, the study will invite relatives of patients with high Lp(a) to undergo testing for this hereditary risk factor. The research will be conducted across six hospitals in Sweden, focusing on the genetic implications of Lp(a) levels and their relationship to cardiovascular disease. The findings could provide insights into the effectiveness of cascade screening for identifying at-risk individuals.
Who should consider this trial
Good fit: Ideal candidates include individuals with established atherosclerotic coronary artery disease who are participating in the clinical health care development project.
Not a fit: Patients diagnosed with familial hypercholesterolemia or chronic kidney disease stage 4 or higher may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier identification and management of cardiovascular risk in relatives of affected patients.
How similar studies have performed: While cascade screening has been effective for familial hypercholesterolemia, its application for elevated Lp(a) levels is novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria * participation in the clinical health care development project * established atherosclerotic coronary artery disease Exclusion Criteria: * diagnosis of familial hypercholesterolemia * chronic kidney disease stadium ≥4
Where this trial is running
Stockholm
- Karolinska university hospital — Stockholm, Sweden (RECRUITING)
Study contacts
- Study coordinator: Jonas Brinck, MD PhD
- Email: jonas.brinck@ki.se
- Phone: +46-70-3029748
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiovascular Diseases, Dyslipidemias, Hereditary Diseases, Lipoprotein, Coronary artery disease, Cascade screening, Atherosclerotic cardiovascular disease