Evaluating C7 Nerve Transfer for Stroke Recovery
Official title: Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke
Run by Dartmouth-Hitchcock Medical Center · NCT06001736 · Data updated 2026-11-12
This study is testing if a surgery that connects a healthy part of the brain to the arm can help people who haven't improved their arm function after a stroke for 1-5 years.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 95 (estimated) |
| Sponsor | Dartmouth-Hitchcock Medical Center Academic / other |
| Locations | 1 site (Lebanon, New Hampshire) |
| Status | Recruiting |
| Started | March 13, 2022 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | February 27, 2026 |
| Trial ID | NCT06001736 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals who have suffered an ischemic or hemorrhagic stroke resulting in arm paresis that has plateaued for 1-5 years.
✕Probably not a fit
Patients who are pregnant or have not experienced a stroke will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to assess the effectiveness of contralateral C7 root transfer in improving limb function in patients who have experienced ischemic or hemorrhagic strokes. The procedure seeks to enhance recovery by creating a connection between the healthy side of the brain and the affected arm, leveraging neural reorganization that occurs post-stroke. Participants will be individuals who have not seen improvement in arm function for 1-5 years following their stroke. The study will involve surgical intervention and subsequent evaluation of limb functionality.
Why it matters
Potential benefit: If successful, this approach could significantly improve arm function and quality of life for stroke survivors with persistent limb paresis.
How similar studies have gone: Previous studies on contralateral nerve transfer for similar conditions have shown promising results, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation. * baseline Fugl-Meyer score below 33 Exclusion Criteria: * pregnancy
Where it's running
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Dartmouth-Health
Lebanon, New Hampshire, United States Recruiting
Study contacts
- Principal investigator: Jennifer Hong, Dr. — Dartmouth-Hitchcock Medical Center
- Study coordinator: Lauren Sinks
- Email: Lauren.J.Sinks@hitchcock.org
- Phone: (603) 653-9021
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing a new Emergency Stroke Unit that uses a mobile MRI to see if it can help treat stroke patients faster and improve their recovery.
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Understanding how vision loss affects driving in virtual reality
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Early rehabilitation using EEG neurofeedback for stroke recovery
This study tests if using brainwave feedback along with regular rehab can help stroke patients recover better use of their arms.
-
Longitudinal study on stroke recovery and biomarkers
This study looks at how stroke survivors recover over time by tracking their brain and thinking skills along with changes in their blood to see what helps them get better.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.