Clinical trial Recruiting at 1 site Interventional Ages 18 to 65

Evaluating C7 Nerve Transfer for Stroke Recovery

Official title: Seventh Cervical Nerve Transfer for Spastic Arm Paresis: A Prospective Analysis of Efficacy in Ischemic vs. Hemorrhagic Stroke

Run by Dartmouth-Hitchcock Medical Center · NCT06001736 · Data updated 2026-11-12

This study is testing if a surgery that connects a healthy part of the brain to the arm can help people who haven't improved their arm function after a stroke for 1-5 years.

Quick facts

Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment95 (estimated)
SponsorDartmouth-Hitchcock Medical Center
Academic / other
Locations1 site (Lebanon, New Hampshire)
StatusRecruiting
StartedMarch 13, 2022
Main results expectedMarch 1, 2027
Study endsMarch 1, 2027
Registry record updatedFebruary 27, 2026
Trial IDNCT06001736 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are individuals who have suffered an ischemic or hemorrhagic stroke resulting in arm paresis that has plateaued for 1-5 years.

Probably not a fit

Patients who are pregnant or have not experienced a stroke will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the effectiveness of contralateral C7 root transfer in improving limb function in patients who have experienced ischemic or hemorrhagic strokes. The procedure seeks to enhance recovery by creating a connection between the healthy side of the brain and the affected arm, leveraging neural reorganization that occurs post-stroke. Participants will be individuals who have not seen improvement in arm function for 1-5 years following their stroke. The study will involve surgical intervention and subsequent evaluation of limb functionality.

Why it matters

Potential benefit: If successful, this approach could significantly improve arm function and quality of life for stroke survivors with persistent limb paresis.

How similar studies have gone: Previous studies on contralateral nerve transfer for similar conditions have shown promising results, indicating potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* History of ischemic or hemorrhagic stroke with resultant arm paresis that has ceased to improve within 1-5 years of rehabilitation.
* baseline Fugl-Meyer score below 33

Exclusion Criteria:

* pregnancy

Where it's running

  • Dartmouth-Health
    Lebanon, New Hampshire, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.