Evaluating brain blood flow during organ transplant procedures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the surgical technique of Abdominal Normothermic Regional Perfusion (A-NRP) in organ donors determined by circulatory criteria. It will utilize a multimodal neuromonitoring protocol to continuously monitor brain blood flow and activity during the A-NRP procedure. The study will involve multiple centers and will enroll eligible DCC donors, with neurocritical care teams implementing various monitoring techniques such as Transcranial colour-coded Doppler, Electroencephalography, and Somatosensory evoked potentials. The goal is to confirm that there is no resumption of brain blood flow or activity during A-NRP, ensuring donor safety and guiding clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≤ 18 years of age
* Potential DCC donors whose families/surrogate decision makers have consented to DCC organ donation according to current criteria of the participating transplant programs. These may include patients donating a liver, kidneys, pancreas, and/or lungs; please see Appendix A for organ specific donor inclusion criteria.

Exclusion Criteria:

* \< 18 years of age
* DCC donors who proceed to donation following medical assistance in dying or those who are able to provide first-person consent at the time of donation
* Injuries that anatomically preclude the use of neurological monitoring

Where it's running

• London Health Sciences Centre
  London, Ontario, Canada Recruiting
• Toronto Western Hospital
  Toronto, Ontario, Canada Not yet recruiting

Study contacts

• Principal investigator: Anton Skaro, MD PhD — London Health Sciences Centre/Lawson Health Research Institute
• Study coordinator: Crystal Engelage, PhD
• Email: Crystal.Engelage@lhsc.on.ca
• Phone: 519-685-8500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.