Evaluating Botox for Overactive Bladder Using cineMRI
CineMRI/UDS for Evaluating the Physiologic Effect of Botox in Women With Overactive Bladder
NA · Cedars-Sinai Medical Center · NCT02315950
This study is testing if Botox can help women with overactive bladder who haven't found relief from other treatments by using special imaging to see how it works.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Ages | 21 Years and up |
| Sex | Female |
| Sponsor | Cedars-Sinai Medical Center (other) |
| Locations | 1 site (Beverly Hills, California) |
| Trial ID | NCT02315950 on ClinicalTrials.gov |
What this trial studies
This study aims to improve treatment for women suffering from overactive bladder (OAB) symptoms by utilizing time-resolved cine MRI combined with urodynamics to assess the effects of intravesical botulinum toxin. The researchers will investigate how Botox alleviates urgency and urge incontinence in patients who have not responded to other medical therapies. By employing advanced imaging techniques, the study seeks to better understand the physiological mechanisms at play and optimize the placement of Botox injections to enhance treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 21 years or older who experience symptoms of overactive bladder.
Not a fit: Patients who are under 21 years of age, unable to provide informed consent, or who suffer from claustrophobia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatment options for women with medication-refractory overactive bladder.
How similar studies have performed: While the use of botulinum toxin for OAB has been established, the application of cineMRI-UDS to evaluate its effects is a novel approach that has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female * Age 21 years or older * Overactive bladder symptoms Exclusion Criteria: * Age less than 21 years * Inability to give informed consent * Claustrophobic
Where this trial is running
Beverly Hills, California
- Cedars-Sinai Medical Center — Beverly Hills, California, United States (RECRUITING)
Study contacts
- Principal investigator: Jennifer Anger, MD, MPH — Cedars-Sinai Medical Center
- Study coordinator: Jennifer Anger, MD, MPH
- Phone: 3103852992
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Overactive Bladder