Evaluating blood pressure effects on kidney function in septic shock

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between mean arterial pressure (MAP) and renal resistive index in patients experiencing septic shock. It aims to determine if an increase in MAP from 65 mmHg to 85 mmHg can predict improved renal function, as measured by changes in renal resistive index. Patients will be monitored after stabilization at both MAP levels, and their renal function will be assessed on the seventh day. The trial will involve randomizing patients into two groups based on their response to the renal resistive index.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult patients (≥ 18 ans)
* Admitted to the intensive care unit of Angers with
* arterial hypotension requiring the etablishment of catecholamines
* In a context of proven or suspected sepsis, whaterver the cause of this infection.
* norepinephrine dose ⩾ 0.1µg/kg/min
* After 2 hours of stabilization at 65 mmHg of mean arterial pressure

Exclusion Criteria:

* Pre-existing chronic renal failure (glomerular filtration rate \< 60 mL/min with MDRD)
* Solitary kidney (anatomical or functional)
* History of united or bilateral stenosis of the renal arteries
* decision to stop or limit treatment
* patient with an emergency indication of renal replacement therapy (severe hyperkalemia, severe metabolical acidosis with pH \<7.15, acute pulmonary edema due to fluid overload resulting in severe hypoxemia, serum urea concentration \> 40 mmol/l and oliguria/anuria \> 72 h.)
* pregnant, lactating or parturient woman
* patient deprived of liberty by judicial or administrative decision
* patient with psychiatric compulsory care
* patient subject to legal protection measures

Where it's running

• CHU Angers. Médecine Intensive Réanimation et médecine hyperbare
  Angers, France Recruiting

Study contacts

• Principal investigator: Pierre ASFAR, MD PHD — University Hospital, Angers
• Study coordinator: Nicolas FAGE, Resident
• Email: fage.nicolas@gmail.com
• Phone: 0241355865

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.