Evaluating blood flow changes during a specific conditioning procedure in critically ill patients
Hemodynamic Variations During Remote Ischemic Conditioning in Critical Ill Patients
NA · Lithuanian University of Health Sciences · NCT06536231
This study is testing whether a special procedure called remote ischemic conditioning can improve blood flow and heart function in critically ill patients compared to simply raising their legs.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | Lithuanian University of Health Sciences (other) |
| Locations | 1 site (Kaunas) |
| Trial ID | NCT06536231 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the hemodynamic changes that occur during remote ischemic conditioning (RIC) in critically ill patients. It will compare these changes to those induced by passive leg raising, hypothesizing that RIC will enhance stroke volume, cardiac index, and peripheral perfusion. The study will utilize a transpulmonary thermodilution device for monitoring and aims to clarify the clinical relevance of RIC in determining hemodynamic responsiveness in this patient population.
Who should consider this trial
Good fit: Ideal candidates are critically ill patients over 18 years old who are admitted to the intensive care unit and monitored with specific hemodynamic devices.
Not a fit: Patients with advanced malignancy, pregnancy, or certain vascular conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve hemodynamic management in critically ill patients, potentially enhancing their recovery outcomes.
How similar studies have performed: While the concept of remote ischemic conditioning has been explored, the specific application in critically ill patients remains novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * aged over 18 years, * admitted to the intensive care unit, * monitored with a transpulmonary thermodilution device with calibrated pulse contour analysis (Pulsion Medical Systems, Munich, Germany), * decision by the physician in charge to perform passive leg raising. Exclusion Criteria: * pregnancy, * advanced malignancy, * peripheral artery disease affecting both arms, * head trauma, * deep vein thrombosis in the lower limbs, * intra-abdominal hypertension, defined as an intra-abdominal pressure greater than 12 mmHg.
Where this trial is running
Kaunas
- The Hospital of Lithuanian University of Health Sciences Kauno klinikos, department of Intensive care — Kaunas, Lithuania (RECRUITING)
Study contacts
- Principal investigator: Andrius Pranskunas, PhD, prof. — Lithuanian University of Health Sciences
- Study coordinator: Andrius Pranskunas, PhD, prof.
- Email: andrius.pranskunas@lsmu.lt
- Phone: +37037326425
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Critical Illness, Remote ischemic conditioning, Passive leg raising, Hemodynamic, Perfusion index, Fluid responsiveness