Evaluating biomarkers in transplant recipients to enhance outcomes
Official title: Study of Biomarkers in Solid Organ and Bone Marrow Transplant Recipients to Better Treat Rejection
Run by University of Pittsburgh · NCT01163578 · Data updated 2026-11-12
This study is testing if measuring certain proteins in blood and saliva can help doctors understand how well transplant medications are working for people who have received solid organ or bone marrow transplants.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 1200 (estimated) |
| Sponsor | University of Pittsburgh Academic / other |
| Locations | 1 site (Pittsburgh, Pennsylvania) |
| Status | Recruiting |
| Started | March 2005 |
| Main results expected | March 2030 |
| Study ends | March 2030 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT01163578 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include recipients of abdominal, thoracic, and bone marrow allografts who are undergoing routine follow-up at the University of Pittsburgh Medical Center.
✕Probably not a fit
Patients who are unable to read and understand informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess specific proteins in biological tissues to better understand the effects of drugs used to treat rejection in solid organ and bone marrow transplant recipients. Participants will provide blood and saliva samples during routine clinical tests, allowing for longitudinal analysis of biomarker expression and its correlation with clinical drug concentrations. The study will involve monitoring drug levels and laboratory tests to evaluate immunosuppression adequacy and allograft function over time.
Why it matters
Potential benefit: If successful, this study could lead to improved management of transplant rejection and better outcomes for transplant recipients.
How similar studies have gone: Other studies have shown promise in using biomarkers to predict transplant outcomes, indicating that this approach has potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Recipients of abdominal, thoracic and bone marrow allografts that are receiving inpatient and outpatient follow-up with routine laboratory tests at the University of Pittsburgh Medical Center. * All Ages * Subject or parents are able to read and understand the informed consent Exclusion Criteria: * Subjects and/or their parents who are unable to read and understand informed consent.
Where it's running
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States Recruiting
Study contacts
- Principal investigator: Rakesh Sindhi, MD — University of Pittsburgh
- Study coordinator: Morgan L Paul, BSN
- Email: Morgan.Paul2@upmc.edu
- Phone: 412-692-8472
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Dexcom G7 CGM in critically ill adults after major abdominal surgery or solid organ transplant
This study tests how accurately the Dexcom G7 continuous glucose monitor tracks glucose in ICU patients after major abdominal surgery or solid organ transplantation who need tight insulin control.
-
Low-dose ATG/PTCy plus ivarmacitinib to prevent acute GVHD after haploidentical PBSC transplant from parous female donors
This tests whether adding the oral JAK1 inhibitor ivarmacitinib to low-dose ATG and post‑transplant cyclophosphamide can prevent acute GVHD in adults receiving haploidentical peripheral blood stem cell transplants from parous female donors.
-
Long-term health of children born to mothers who had a solid organ transplant
This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.
-
High-altitude stem cell and bone marrow transplant registry on the Qinghai-Tibet Plateau
This project will collect clinical data and blood/bone marrow samples from people having hematopoietic stem cell transplants on the Qinghai‑Tibet Plateau to see how high altitude affects transplant outcomes and recovery.
-
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This study looks at inflammation and certain biological markers in organ transplant patients to see if it can help identify those at higher risk for complications and improve their treatment.
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This study is trying to understand the genetic and environmental factors that cause kidney diseases and their complications to help improve treatment and care for people at risk or already diagnosed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.