Evaluating biomarkers in gum disease treatment outcomes
Prognostic Potentials of E-cadherin and Total Antioxidant Capacity in Gingival Crevicular Fluid of Moderately Deep Periodontal Pockets Treated With Nonsurgical Periodontal Therapy
This study is testing if certain markers in gum fluid can help predict how well people with gum disease will respond to treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Baghdad Academic / other |
| Locations | 1 site (Baghdad) |
| Trial ID | NCT05994885 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the prognostic potential of E-cadherin and total antioxidant capacity in gingival crevicular fluid to predict treatment outcomes for patients with periodontitis. By analyzing these biomarkers alongside clinical parameters, the research seeks to enhance the accuracy of treatment planning for periodontal therapy. Participants will undergo root surface debridement, and their responses will be monitored to determine the effectiveness of these biomarkers in predicting healing and treatment success.
Who should consider this trial
Good fit: Ideal candidates are systemically healthy adults over 18 years with generalized periodontitis and specific clinical attachment loss.
Not a fit: Patients with severe periodontal pockets, systemic diseases, or those who have recently undergone antibiotic treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and effective treatment plans for patients with periodontitis.
How similar studies have performed: While the use of biomarkers in periodontal disease is gaining attention, this specific approach focusing on E-cadherin and TAC in gingival crevicular fluid is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Systemically healthy adult patients (\> 18 years). * Periodontitis (interdental clinical attachment loss (CAL) detectable at ≥2 non-adjacent teeth, or buccal/oral CAL of ≥3mm with pocketing of \>3mm is detectable at ≥2 teeth). All patients should exhibit generalized periodontitis with pockets of PPD = 4 to 6 mm of any stage, unstable, and grade A to C. Only maxillary teeth with single root will be included. Exclusion Criteria: * Consumption of antibiotics or periodontal treatment 3-months prior to the study. * Pregnancy and lactation. * Smoker. * History of systemic disease e.g., diabetes mellitus. * Patients currently recruited in other trials. * Patients not willing to consent. * Periodontal pockets ≥ 7mm, active caries, endodontic problem. * Multi-rooted teeth will be also considered as exclusion reasons.
Where this trial is running
Baghdad
- College of Dentistry/ University of Baghdad — Baghdad, Iraq (Recruiting)
Study contacts
- Study coordinator: Ali A Abdulkareem, PhD
- Email: ali.abbas@codental.uobaghdad.edu.iq
- Phone: 07806866717
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.