Evaluating biomarkers for delirium in elderly cardiac surgery patients

Study on Biomarkers of Postoperative Delirium in Elderly Cardiac Surgery Patients

This study is trying to see if certain blood markers can help predict delirium in older patients aged 55 to 80 who are having heart surgery.

Quick facts

• Study type: Observational
• Enrollment: 24 (estimated)
• Ages: 55 Years to 80 Years
• Sex: All
• Sponsor: Jining First People's Hospital (Academic / other)
• Locations: 1 site (Jining, Shandong)
• Trial ID: NCT06194474 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess the relationship between abnormal protein or metabolite levels in the blood and the occurrence of postoperative delirium in elderly patients undergoing cardiac surgery. It focuses on patients aged 55 to 80 with specific health statuses and planned surgeries. By analyzing blood samples, the study seeks to identify potential biomarkers that could predict delirium, thereby improving patient outcomes and care strategies.

Who should consider this trial

Good fit: Ideal candidates for this study are elderly patients aged 55 to 80 who are scheduled for cardiac surgery and meet specific health criteria.

Not a fit: Patients with pre-existing cognitive impairments, psychiatric disorders, or those currently using sedatives or antidepressants may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to better identification and management of patients at risk for postoperative delirium, enhancing recovery and overall patient care.

How similar studies have performed: While the approach of identifying biomarkers for delirium is being explored, this specific study's focus on elderly cardiac surgery patients may provide novel insights.

Eligibility criteria

Inclusion Criteria:

1. patients between 55 and 80 years old,
2. American Society of Anesthesiologists (ASA) physical status of II-III and New York Heart Association grade of II-III.
3. The planned cardiac surgery.
4. Hospitalization duration not less than 5 days.
5. The anesthesia time will be no less than 2 hours.All patients had a normal ability to hear, read and cooperate with neuropsychological tests.

Exclusion Criteria:

1. The pre-operative Montreal Cognitive Assessment (MoCA) score was less than 25,
2. Patients with dementia, history of neurological or psychiatric disease, hospital with anxiety depression scale (HADS) over eight points,
3. Currently use sedatives or antidepressants, Patients with substance dependence on drugs or alcohol.
4. Patients with liver and kidney dysfunction, patients with a history of cardiac surgery.
5. Admitted to the ICU for more than two days within the month preceding the current surgery,
6. Unable to cooperate with researcher's investigations.

Where this trial is running

Jining, Shandong

• Fuhui Yan — Jining, Shandong, China (Recruiting)

Study contacts

• Study coordinator: Fuhui Yan

Conditions Delirium