Evaluating aortic stiffness in patients with genetic aortopathies

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess arterial stiffness in patients with thoracic ascending aortic aneurysms, both syndromic and non-syndromic. Participants will undergo non-invasive evaluations to measure blood pressure and arterial stiffness using Pulse Wave Velocity (PWV). The study seeks to stratify aortic risk based on these measurements and compare them with morphological and hemodynamic features of the ascending thoracic aorta. The findings could provide insights into the relationship between aortic stiffness and aneurysm markers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects with AAT, either syndromic or non syndromic;
* Signed informed consent

Exclusion Criteria:

* Patients with early menopause and/or osteoporosis, rheumatic heart disease and active malignant tumours;
* Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system;
* Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2;
* Pregnancy

Where it's running

• IRCCS Policlinico San Donato
  San Donato Milanese, Lombardy, Italy Recruiting

Study contacts

• Principal investigator: Alessandro Pini — Cardiovascular-Gentic Centre, IRCCS Policlinico San Donato
• Study coordinator: Alessandro Pini, MD
• Email: alessandro.pini@grupposandonato.it
• Phone: +390252774705

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.