Evaluating anticoagulation management during pregnancy and postpartum

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study is an international multicenter prospective cohort that assesses anticoagulation management strategies around labor, delivery, and the postpartum period. It aims to collect quality data on postpartum bleeding events, venous thromboembolism (VTE) risk, delivery experiences, and healthcare utilization for individuals on low-molecular-weight heparin (LMWH) during pregnancy. By standardizing outcome definitions, the study seeks to improve understanding of the implications of anticoagulation management in pregnant individuals.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older
* Requires anticoagulation during the antepartum period of pregnancy for a VTE indication, including at least one of:

  1. Objectively confirmed VTE (DVT, superficial vein thrombosis \[SVT\], PE or unusual site thrombosis) diagnosed during the current pregnancy;
  2. Objectively confirmed VTE diagnosed in a prior pregnancy;
  3. Objectively confirmed VTE diagnosed when not pregnant;
  4. Inherited or acquired thrombophilia requiring anticoagulation.
* Receiving any dose or type of LMWH during the antepartum period

Exclusion Criteria:

* Anticoagulation for a non-VTE indication, including prosthetic heart valves, atrial fibrillation, prevention of placenta-mediated pregnancy complications, or prevention of recurrent pregnancy loss (participants can be included with a diagnosis of antiphospholipid syndrome (APS) with or without thrombotic events)
* Unable to provide or declined consent.
* Home or birthing centre planned delivery.

Where it's running

• Duke University Hospital
  Durham, North Carolina, United States Recruiting
• Foothills Medical Centre
  Calgary, Alberta, Canada Recruiting
• Royal Alexandra Hospital
  Edmonton, Alberta, Canada Recruiting
• BC Women's Hospital and Health Centre
  Vancouver, British Columbia, Canada Recruiting
• St. Boniface Hospital
  Winnipeg, Manitoba, Canada Recruiting
• McMaster University Medical Centre
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Leslie Skeith, MD — University of Calgary
• Study coordinator: Jill Baxter, BSc
• Email: jbaxter@ucalgary.ca
• Phone: 403-220-7103

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.