Evaluating amino acid needs in ovarian cancer patients
Evaluation of Amino Acid Metabolism Changes in Participants With Ovarian Cancer by Dynamic Test
This study is testing the specific amino acid needs of patients with high-grade serous ovarian cancer to see how better nutrition can help manage weight loss and improve their health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 23 (estimated) |
| Ages | 40 Years to 70 Years |
| Sex | Female |
| Sponsor | University Hospital, Grenoble Academic / other |
| Locations | 1 site (La Tronche) |
| Trial ID | NCT06216496 on ClinicalTrials.gov |
What this trial studies
This study focuses on understanding the changes in amino acid metabolism in patients with high-grade serous ovarian cancer who are not immediately resectable. The goal is to identify specific amino acid requirements to better manage undernutrition and cachexia, which are common in cancer patients. By conducting a dynamic test for amino acid metabolism, the researchers aim to optimize nutritional support tailored to the needs of these patients. This approach seeks to improve the effectiveness of nutritional interventions in combating cachexia.
Who should consider this trial
Good fit: Ideal candidates for this study are patients with a histological diagnosis of high-grade serous ovarian cancer at stage III or IVa who are managed at Grenoble Alpes University Hospital.
Not a fit: Patients with significant active comorbidities affecting amino acid metabolism or those following a vegetarian or vegan diet may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective nutritional strategies that improve the quality of life and outcomes for ovarian cancer patients experiencing cachexia.
How similar studies have performed: While the specific approach of this study may be novel, there is a growing body of research indicating that tailored nutritional interventions can improve outcomes in cancer patients.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Histological diagnosis of high-grade serous ovarian cancer not immediately resectable (stage III or IVa) managed at Grenoble Alpes University Hospital. * Affiliation to the French social security system. * Able to understand and follow the instructions necessary for the conduct of the trial, and having given written consent for the study. Exclusion Criteria: * Significant active comorbidity requiring long-term drug treatment (e.g. organ failure, diabetes) or history of pathology likely to impact amino acid metabolism (e.g. urea or homocysteine cycle abnormalities, tyrosinemia, alkaptonuria, hyperprolinemia, organic aciduria). * vegetarian or vegan diet * difficult venous access * Persons covered by articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons subject to a legal protection measure). * Subject receiving more than 4,500 euros in compensation for participation in other research involving the human body in the 12 months preceding this study. * Significant biological abnormalities (not explained by the underlying pathology for women with ovarian cancer) * Liver metastases
Where this trial is running
La Tronche
- CHU Grenoble Alpes — La Tronche, France (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.