Evaluating air purifiers for improving allergic rhinitis symptoms
Clinical Validation of the Efficacy of Air Purifiers Equipped With Harmful Gas Filters in Improving Indoor Environment and Alleviating Allergic Symptoms in Allergic Rhinitis Patients
This study is testing whether using a special air purifier can help adults with moderate to severe allergies feel better compared to using a fake air purifier.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 44 (estimated) |
| Ages | 19 Years to 60 Years |
| Sex | All |
| Sponsor | Yonsei University Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT06890572 on ClinicalTrials.gov |
What this trial studies
This study focuses on adults aged 19 to 60 diagnosed with moderate to severe persistent allergic rhinitis caused by indoor inhalation antigens. Participants will use either a HEPA + VOC air purifier or a fake air purifier over two four-week periods, with a two-week break in between. The study aims to objectively and subjectively assess the improvement in rhinitis symptoms through regular visits and symptom scoring. Random assignment ensures unbiased results regarding the efficacy of the air purifiers.
Who should consider this trial
Good fit: Ideal candidates are adults aged 19 to 60 with moderate to severe persistent allergic rhinitis requiring ongoing medication.
Not a fit: Patients with seasonal allergies or those not spending significant time indoors may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological option for managing allergic rhinitis symptoms in patients.
How similar studies have performed: While the use of air purifiers has been explored, this specific randomized approach comparing a functional and a fake purifier is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adults aged 19 to 60 * A person with moderate-severe persistent allergic rhinitis diagnosed by an allergy specialist or otolaryngologist and maintained without any change in treatment for more than one month * Total nasal symptom Score ≥ 8 * Patients with allergic rhinitis caused by indoor inhalation antigen antigens (House dust mites ± If the wheal size of the pet skin test is greater than 3mm or the concentration of specific IgE measured by ImmunoCAP ≥ 0.35 kUA/L) * A person who spends at least 8 hours/day per week in the home where the cleaner will be installed * A person with a wi-fi installed in the home where the purifier will be installed * A person who can read and write in Korean * A person who fully explains the contents, decides to participate in the study according to his/her free will, and signs a written consent form approved by each agency IRB Exclusion Criteria: * Patients sensitized to seasonal antigens (tree, grass or weed pollen) * Rhinitis patients caused by causes other than allergic rhinitis (drug rhinitis, vascular rhinitis, infectious rhinitis, etc.) * Anyone who has required more than 2 weeks of systemic steroid use in the last 3 months * A person taking antihistamines for reasons other than rhinitis (chronic urticaria, etc.) * Those with anatomical abnormalities that cause nasal congestion, such as non-segmental curvature and non-segmental species * A person who has a plan to move during the study period or is scheduled to leave where air purifiers are installed for at least five consecutive days (e.g., travel, business trip, etc.) * A person who has already used an air purifier within the last three months * Pregnant women, lactating women, persons lacking decision-making ability, persons accommodated in facilities * A person whose researcher is deemed unfit to participate in clinical research due to other reasons
Where this trial is running
Seoul
- Yonsei University — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Kyung Hee Park — Yonsei University Health System, Severance Hospital
- Study coordinator: Kyung Hee Park
- Email: white182@yuhs.ac
- Phone: +82-2-2228-1947
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.