Evaluating air purifiers for improving allergic rhinitis symptoms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on adults aged 19 to 60 diagnosed with moderate to severe persistent allergic rhinitis caused by indoor inhalation antigens. Participants will use either a HEPA + VOC air purifier or a fake air purifier over two four-week periods, with a two-week break in between. The study aims to objectively and subjectively assess the improvement in rhinitis symptoms through regular visits and symptom scoring. Random assignment ensures unbiased results regarding the efficacy of the air purifiers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adults aged 19 to 60
* A person with moderate-severe persistent allergic rhinitis diagnosed by an allergy specialist or otolaryngologist and maintained without any change in treatment for more than one month
* Total nasal symptom Score ≥ 8
* Patients with allergic rhinitis caused by indoor inhalation antigen antigens (House dust mites ± If the wheal size of the pet skin test is greater than 3mm or the concentration of specific IgE measured by ImmunoCAP ≥ 0.35 kUA/L)
* A person who spends at least 8 hours/day per week in the home where the cleaner will be installed
* A person with a wi-fi installed in the home where the purifier will be installed
* A person who can read and write in Korean
* A person who fully explains the contents, decides to participate in the study according to his/her free will, and signs a written consent form approved by each agency IRB

Exclusion Criteria:

* Patients sensitized to seasonal antigens (tree, grass or weed pollen)
* Rhinitis patients caused by causes other than allergic rhinitis (drug rhinitis, vascular rhinitis, infectious rhinitis, etc.)
* Anyone who has required more than 2 weeks of systemic steroid use in the last 3 months
* A person taking antihistamines for reasons other than rhinitis (chronic urticaria, etc.)
* Those with anatomical abnormalities that cause nasal congestion, such as non-segmental curvature and non-segmental species
* A person who has a plan to move during the study period or is scheduled to leave where air purifiers are installed for at least five consecutive days (e.g., travel, business trip, etc.)
* A person who has already used an air purifier within the last three months
* Pregnant women, lactating women, persons lacking decision-making ability, persons accommodated in facilities
* A person whose researcher is deemed unfit to participate in clinical research due to other reasons

Where it's running

• Yonsei University
  Seoul, South Korea Recruiting

Study contacts

• Principal investigator: Kyung Hee Park — Yonsei University Health System, Severance Hospital
• Study coordinator: Kyung Hee Park
• Email: white182@yuhs.ac
• Phone: +82-2-2228-1947

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.