Evaluating advanced sequencing for diagnosing spinal infections
Official title: Diagnostic Efficacy of Metagenomic Next-generation Sequencing in Patients With Spinal Infections: A Retrospective Study
Run by Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · NCT06172153 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if a new DNA sequencing method can do a better job than standard lab tests at diagnosing spinal infections in patients who might have them.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06172153 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients suspected of spinal infections based on specific clinical criteria.
✕Probably not a fit
Patients who do not undergo the necessary laboratory and histopathological examinations will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the effectiveness of traditional laboratory methods with second-generation high-throughput sequencing in diagnosing spinal infections. It focuses on patients suspected of having these infections based on established clinical criteria. The study is observational and retrospective, analyzing data from patients who underwent various diagnostic examinations, including laboratory tests and imaging. The goal is to determine if metagenomic sequencing provides superior diagnostic accuracy compared to conventional methods.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate and timely diagnoses of spinal infections, improving patient outcomes.
How similar studies have gone: While this approach is innovative, similar studies using advanced sequencing techniques have shown promising results in other infection diagnostics.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: "Patients suspected of spinal infections, as per the American Infectious Diseases Society's 2015 criteria for primary vertebral osteomyelitis, were identified based on their clinical symptoms, laboratory tests, and imaging examinations. All cases included in the study underwent laboratory examinations, histopathological examinations, and second-generation high-throughput sequencing (metagenomic sequencing)." Exclusion Criteria: "The absence of laboratory examinations, histopathological examinations, and results from second-generation high-throughput sequencing (metagenomic sequencing)."
Where it's running
-
Sun Yat-sen memorial hospital
Guangzhou, Guangdong, China Recruiting
Study contacts
- Principal investigator: Chunhai Li, MD — Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Study coordinator: Chunhai Li, MD
- Email: lichhai@mail.sysu.edu.cn
- Phone: 18602079796
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.