Evaluating a new ventilation method for cardiac arrest patients
Chest Compression Synchronized Ventilation (CCSV) - an Exploratory Post Market Clinical Follow-up Study
This study is testing a new way to help people who have had a cardiac arrest breathe better during CPR to see if it improves their chances of recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 98 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Medical University of Vienna Academic / other |
| Locations | 1 site (Vienna, Austria) |
| Trial ID | NCT06836908 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of Chest Compression Synchronized Ventilation (CCSV) compared to Intermittent Positive Pressure Ventilation (IPPV) in patients experiencing cardiac arrest. The study will assess various outcomes including oxygenation levels, hemodynamic effects, and safety over a 30-day period. Patients in Vienna, Austria will be preclinically randomized to receive either ventilation method during CPR, with data collected on their oxygenation, systemic perfusion, and any adverse events related to ventilation. The goal is to provide insights into the best ventilation strategy for improving patient outcomes in cardiac arrest situations.
Who should consider this trial
Good fit: Ideal candidates for this study are patients experiencing out-of-hospital cardiac arrest who are being treated by the Vienna Emergency Medical Services.
Not a fit: Patients who are recovering before mechanical ventilation begins or those with traumatic cardiac arrest may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ventilation strategies that enhance survival rates and recovery outcomes for cardiac arrest patients.
How similar studies have performed: While data on CCSV in humans is sparse, this study aims to fill a gap in knowledge, suggesting that it may be a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * OHCA * Correct endotracheal intubation (seen by capnography) * The patient is being treated by the Vienna Emergency Medical Services within the scope of emergency ventilation. * MEDUMAT Standard from Weinmann Emergency is used. * Mechanical ventilation is performed according to the specified indications. Exclusion Criteria: * Patients eligible for eCPR (as defined by the standard operating procedure of the Emergency Medical Service Vienna) * Patients recovering (reaching sustained ROSC) before starting mechanical ventilation or in the first three minutes of it * Any other mechanical ventilation during the ongoing CPR before study inclusion * Traumatic cardiac arrest * Suspected or known pregnancy * Clinically suspected (tension-)pneumothorax
Where this trial is running
Vienna, Austria
- Medical University of Vienna — Vienna, Austria, Austria (Recruiting)
Study contacts
- Principal investigator: Sebastian Schnaubelt, MD, PhD — Department of Emergency Medicine, Medical University of Vienna
- Study coordinator: Sebastian Schnaubelt, MD, PhD
- Email: sebastian.schnaubelt@meduniwien.ac.at
- Phone: +43 1 40400
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.