Evaluating a new treatment for advanced solid tumors

A Phase I Study of Evaluating the Safety and Efficacy of Intravenous IDOV-SAFETM in Patients With Advanced Solid Tumors

This study is testing a new virus injection to see if it can help people with advanced solid tumors that haven't improved with standard treatments.

Quick facts

• Phase: EARLY_PHASE1
• Study type: Interventional
• Enrollment: 19 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences (other)
• Drugs / interventions: chemotherapy, immunotherapy, radiation, prednisone
• Locations: 1 site (Beijing)
• Trial ID: NCT06346041 on ClinicalTrials.gov

What this trial studies

This open-label, dose escalation study assesses the safety and efficacy of IDOV-SAFETM, an oncolytic virus injection, in patients with advanced solid tumors that have not responded to standard treatments. The trial employs a '3+3' design to determine the maximum tolerated dose (MTD) and monitor pharmacokinetics, immunogenicity, and pharmacodynamics. Approximately 13-19 participants will be enrolled based on observed toxicities and treatment activity, with a three-week observation period for dose-limiting toxicities before escalating to the next dose level.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with advanced malignant solid tumors that have either progressed after standard treatment or for which no effective standard treatment exists.

Not a fit: Patients with solid tumors that are responsive to standard treatments or those with significant comorbidities affecting their ability to participate may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new therapeutic option for patients with advanced solid tumors that currently lack effective standard treatments.

How similar studies have performed: While this approach is novel, similar studies using oncolytic viruses have shown promise in treating various cancers, indicating potential for success.

Eligibility criteria

Inclusion Criteria:

* Understand and voluntarily sign a written informed consent;
* Male and female, ≥18 years old and ≤75 years old;
* Histologically or cytologically confirmed advanced malignant solid tumors that do not respond to standard treatment (disease progression or treatment intolerance after treatment) or currently lack effective standard treatment (including but not limited to advanced MSS colorectal cancer);
* ECOG physical status score 0\~1;
* Expected survival ≥3 months;
* At least one evaluable lesion according to the solid tumor response criteria (RECIST version 1.1). Note: If the only evaluable disease site has previously received radiation therapy, it can be considered an evaluable lesion after determining disease progression;
* Major organ and bone marrow functions meet the following criteria within 7 days prior to initial dosing:

  1. Blood routine: neutrophils ≥1.5×109/L, platelets \> 100×109/L, hemoglobin ≥90g/L(no blood transfusion, no supportive treatment with G-CSF and other drugs within 2 weeks before screening);
  2. Liver function: General patients: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST)≤3× upper limit of normal; Total bilirubin ≤1.5× upper limit of normal value; Patients with liver metastasis: ALT and/or AST ≤5× upper limit of normal;
  3. Renal function: serum creatinine (Cr)≤1.5× upper limit of normal value or creatinine clearance CCr≥60ml/min(using Cockcroft-Gault formula: The Ccr (ml/min) = \[(140 - age) \* weight kg \* F\] / \[serum creatinine (mg/dl) x 72\] (F = 1 male, the female F = 0.85).
  4. Coagulation function: prothrombin time (PT)≤ 1.5×ULN or International Normalized ratio (INR)≤ 1.5×ULN, and activated partial thromboplastin time (APTT)≤ 1.5×ULN;
* The blood pregnancy results of fertile female subjects within 7 days prior to the first dosing must be negative. Female subjects were willing to use highly effective contraception during the trial and for at least 90 days after the last dose of the trial drug. Male subjects were willing to use highly effective contraception during the trial and for at least 90 days after the last dose of the trial drug.

Exclusion Criteria:

* Severe systemic reactions or side effects due to prior smallpox vaccination;
* Patients with known to be allergic to the test drug or its excipients;
* Patients with a history of other tumors within 5 years prior to screening, excluding effectively resected cervical carcinoma in situ, low-risk gastrointestinal stromal tumor, breast cancer, cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma, and papillary thyroid carcinoma;
* Patients with untreated symptomatic central nervous system metastases (CNS) who meet one of the following criteria can be enrolled:

  1. CNS metastasis is asymptomatic and does not require treatment;
  2. The CNS metastases have been treated, neurological symptoms have returned to baseline (except for treatment-related residual signs or symptoms), glucocorticoids have been discontinued for at least 2 weeks prior to randomization, and imaging studies within 28 days prior to randomization suggest that the CNS lesions are radiographically stable.
* Pial metastasis;
* Subjects with uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage;
* Previous acceptance of oncolytic viruses, stem cells or gene therapy products;
* Patients with received systemic antitumor therapy, including but not limited to chemotherapy, endocrine therapy, and immunotherapy, within 4 weeks before the first dose; Oral small-molecule targeted drugs are administered 2 weeks before the first dose or within 5 half-lives of the drug (whichever is longer); Palliative radiotherapy within 14 days before the first dose; Participated in clinical trials of other antitumor drugs within 4 weeks; Received any Chinese herbal medicine or proprietary Chinese medicine for any anti-tumor indication within 2 weeks prior to initial administration;
* The adverse reactions of previous anti-tumor therapy have not returned to CTCAE 5.0 grade evaluation ≤ Class 1 (except toxicity judged by the investigator to have no safety risk);
* Patients with received surgery or interventional treatment (excluding tumor biopsy, puncture, etc.) or unhealed wounds, ulcers or fractures within 4 weeks prior to the first dose;
* Patients with a history of severe cardiovascular and cerebrovascular disease, including but not limited to: congestive heart failure ≥ Class II of the New York Heart Association (NYHA); Left ventricular ejection fraction (LVEF)\<50%; QT interval (QTcF)\>470ms as corrected by the Fridericia method or prolonged QT interval syndrome; Acute coronary syndrome, aortic dissection, severe arrhythmia, stroke, or other grade 3 or higher cardiovascular and cerebrovascular events occurred within 6 months before the first treatment; Hypertension poorly controlled by standard treatment (systolic blood pressure ≥140mmHg or diastolic blood pressure ≥90mmHg);
* Patients with a history of exfoliated skin that requires systemic treatment (such as eczema or ectopic dermatitis);
* Active hepatitis B (HbsAg positive, HBV DNA test value greater than the upper limit of normal); Active hepatitis C (those with positive anti-HCV antibodies are further tested positive for HCV RNA); A known history of immunodeficiency virus (HIV) disease or a positive HIV antibody test;
* Subject with an active infection or developed an unexplained fever \> 38.5 ° C during screening or prior to initial administration;
* There is evidence of clinically significant immunodeficiency, such as a primary immunodeficiency state, such as severe combined immunodeficiency disease (SCID); Co-opportunistic infection;
* At the time of screening, patients with active autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, vasculitis, etc., or with a history of autoimmune diseases that may recur, except for the following conditions: (1)Type 1 diabetes; (2)Hypothyroidism (if controlled with hormone replacement therapy alone); (3)Controlled celiac disease; (4)Skin diseases that do not require systemic treatment;(5) Any other disease that will not recur in the absence of an external trigger;
* Subject with an active infection or developed an unexplained fever \> 38.5 ° C during screening or prior to initial administration;are receiving long-term systemic steroid (prednisone \>10mg/ day or equivalent dose of the same drug) or any other form of immunosuppressant therapy within 14 days prior to initial treatment; Treatment with topical, ocular, intra-articular, intranasal, and inhalation corticosteroids is excluded; Short-term use of corticosteroids (≤10mg equivalent dose of prednisone) for preventive treatment (e.g. prevention of contrast agent allergy);
* Patients with received allogeneic tissue or solid organ transplantation;
* Other diseases or abnormalities assessed by the investigator as unsuitable for participation in the study.

Where this trial is running

Beijing

• Cancer Hospital, Chinese Academy of Medical Sciences — Beijing, China (RECRUITING)

Study contacts

• Principal investigator: Ning Li, MD — Cancer Institute and Hospital, Chinese Academy of Medical Sciences
• Study coordinator: Ning Li, MD

Conditions: Neoplasms