Evaluating a new treatment approach for borderline personality disorder
A Pragmatic Non-randomized Controlled Study Evaluating the Efficacy of a Dimensional Adaptation of Good Psychiatric Management (GPM-extended) Compared to a Classic Outpatient Good Psychiatric Management Treatment for Patient Fulfilling Criteria for Borderline Personality Disorder
This study is testing a new personalized treatment for borderline personality disorder to see if it works better than the standard approach.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 154 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | AddiPsy Academic / other |
| Locations | 2 sites (Bayonne and 1 other locations) |
| Trial ID | NCT06913738 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to assess the effectiveness of a dimensional adaptation of Good Psychiatric Management (GPM-extended) compared to classic GPM in treating adults with borderline personality disorder (BPD). The GPM-extended model incorporates elements from adaptations for narcissistic and obsessive-compulsive personality disorders, providing a personalized treatment approach. Researchers will evaluate changes in BPD symptom severity and related clinical outcomes over one year of treatment by comparing two patient groups: those receiving GPM-extended and those receiving classic GPM.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older diagnosed with borderline personality disorder.
Not a fit: Patients with comorbid psychotic disorders, severe antisocial traits, or those unable to cooperate with the study requirements may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved treatment outcomes for patients with borderline personality disorder.
How similar studies have performed: While the dimensional approach to personality disorders is gaining attention, this specific adaptation of GPM has not been widely tested in clinical settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥18 years old) * Diagnosis of borderline personality disorder according to the SCID-II (≥5 out of 9 criteria) * Provision of written informed consent * Affiliated with or beneficiary of the French national health insurance system Exclusion criteria * Age under 18 years * Presence of a comorbid psychotic disorder, intellectual disability, severe antisocial traits, major substance use disorder incompatible with intensive therapy without abstinence, anorexia nervosa with somatic risk, or bipolar disorder in acute manic phase * Individuals under legal protection (e.g., guardianship or legal safeguard) * Individuals unable to cooperate or complete self- or clinician-administered questionnaires * Individuals not affiliated with or not beneficiaries of the French national health insurance system
Where this trial is running
Bayonne and 1 other locations
- Clinique Caradoc — Bayonne, France (Recruiting)
- Addipsy — Lyon, France (Recruiting)
Study contacts
- Principal investigator: Martin Blay, M.D., M.Sc — AddiPsy
- Study coordinator: Martin Blay, M.D., M.Sc
- Email: m.blay@addipsy.com
- Phone: +33472943403
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.