Evaluating a combined therapy for patients recovering from post intensive care syndrome after ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients who have experienced post intensive care syndrome (PIC syndrome) following an ischemic stroke. It aims to evaluate the efficacy of a combined therapy using CYTOFLAVIN® intravenous solution and tablets during the rehabilitation process. The approach emphasizes early rehabilitation interventions to address cognitive, motor, and emotional disorders that arise from prolonged intensive care. The study will include patients who have been in intensive care for at least three days and have moderate-to-severe PIC syndrome.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women over 18 years of age and older;
* Stay in the ITU and (or) intensive care unit for at least 3 days;
* Diagnosed "post intensive care" syndrome (PIC syndrome) with moderate-to-severe severity \>3\<6 points
* Diagnosed modalities "critical illness polyneuropathy, respiratory neuropathy, dysphagia" of the domain "Neuromuscular complications" of PIC syndrome at 2-3 stages of the rehabilitation route at any value of PICS severity index
* Diagnosed modalities "decreased gravitational gradient, decreased exercise tolerance" in the domain "Vegetative-metabolic complications" at 2-3 stages of the rehabilitation route at any value of PICS severity index

Exclusion Criteria:

* Premorbid level of vital activity when assessed on the rehabilitation routing scale 4-5 points;
* Hematocrit ≤30%;
* Hemoglobin level ≤80 g/L;
* Acute cardiac failure;
* Acute respiratory failure;
* Acute renal failure;
* Acute liver cell failure;
* Use of drugs from "metabolic agents" pharmacotherapeutic group at the time of inclusion in the study
* Life expectancy of 6 months or less or presence of incurable diseases in decompensation stage

Where it's running

• Brain Institute Clinic
  Yekaterinburg, Sverdlovsk Oblast, Russia Recruiting

Study contacts

• Study coordinator: Andrey Belkin, MD
• Email: belkin@neuro-ural.ru

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.