EUS-Guided RFA for Pancreatic Lesions: Safety and Outcomes
Official title: Safety and Efficacy of Endoscopic Ultrasound (EUS) Guided Radiofrequency Ablation (RFA) in the Treatment of Pancreatic Lesions: A Pancardinal-4 Prospective Registry
Run by The University of Texas Health Science Center, Houston · NCT07737171 · Data updated 2026-11-12
This study tests whether using endoscopic ultrasound-guided radiofrequency ablation is safe and helps patients with pancreatic lesions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | The University of Texas Health Science Center, Houston Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | April 7, 2026 |
| Main results expected | April 1, 2033 |
| Study ends | April 1, 2033 |
| Registry record updated | July 30, 2026 |
| Trial ID | NCT07737171 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with pancreatic pre-malignant lesions or pancreatic cancer who are undergoing EUS-RFA at the hosting center and can provide informed consent and complete follow-up.
✕Probably not a fit
Patients whose pancreatic lesions do not respond to EUS-RFA or who have contraindications to follow-up may not experience benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 7-year prospective registry at a single center that follows patients who are undergoing EUS-guided radiofrequency ablation for pancreatic lesions. It aims to document safety and efficacy outcomes in real-world practice. The study collects data on patients with pancreatic pre-malignant lesions or pancreatic cancer who are treated with EUS-RFA and are able to complete follow-up.
Why it matters
Potential benefit: If successful, the registry may clarify safety profiles and potential benefits of EUS-RFA for pancreatic lesions, guiding clinical decisions.
How similar studies have gone: Previous studies using EUS-RFA in pancreatic lesions have shown feasibility; this registry will add real-world safety and effectiveness data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of any pancreatic pre-malignant lesion and/or pancreatic malignancy * Patients already undergoing EUS-RFA for treatment of pancreatic lesions clinically Exclusion Criteria: * Patients with co-existing malignancies of other organs (or a prior history of such) * Patients unable to provide informed consent * Patients unable to complete follow-up
Where it's running
-
The University of Texas Health Science Center at Houston
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Nirav Thosani, MD — The University of Texas Health Science Center at Houston (UTHealth Houston)
- Study coordinator: Amatullah Alibhai, MBA
- Email: Amatullah.Alibhai@uth.tmc.edu
- Phone: 713-500-6658
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Integrated genomic and clinical database for cancer biomarker discovery
Researchers are building a combined genomic and clinical database at Samsung Medical Center to test biomarkers for cancer diagnosis, treatment choice, and predicting how well treatments work.
-
Using contrast-enhanced ultrasound to check for local pancreatic cancer recurrence after surgery
This pilot test uses contrast-enhanced ultrasound to see if it can help detect return of pancreatic cancer after surgery in patients being watched with CT scans.
-
Combination of ivermectin with standard skin-protective care for daraxonrasib-related skin toxicity in pancreatic cancer
This study tests whether adding ivermectin to standard preventive skin care helps people with pancreatic cancer who develop skin side effects from daraxonrasib.
-
Becotatug Vedotin Plus Anti-PD-1 and S-1 in EGFR-Positive Advanced Pancreatic Cancer
This study tests a three-drug regimen (becotatug vedotin, an anti-PD-1 therapy, and S-1) in adults with EGFR-positive advanced pancreatic cancer who have not responded to at least one prior therapy.
-
Blood protein biomarkers to help diagnose pancreatic cancer in adults
This study tests whether blood protein biomarkers can help detect pancreatic ductal adenocarcinoma and tell it apart from chronic pancreatitis and mucinous pancreatic lesions, and whether combining markers with CA 19-9 improves accuracy.
-
Lm-LLO-TT and Gemcitabine in Unresectable Pancreatic Cancer (Phase 1)
This early-stage study tests whether giving Lm-LLO-TT directly into the belly with low-dose gemcitabine is safe and tolerable for adults with previously treated, unresectable or metastatic pancreatic cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.