Clinical trial Recruiting at 1 site Observational Ages 18 and up

EUS-Guided RFA for Pancreatic Lesions: Safety and Outcomes

Official title: Safety and Efficacy of Endoscopic Ultrasound (EUS) Guided Radiofrequency Ablation (RFA) in the Treatment of Pancreatic Lesions: A Pancardinal-4 Prospective Registry

Run by The University of Texas Health Science Center, Houston · NCT07737171 · Data updated 2026-11-12

This study tests whether using endoscopic ultrasound-guided radiofrequency ablation is safe and helps patients with pancreatic lesions.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorThe University of Texas Health Science Center, Houston
Academic / other
Locations1 site (Houston, Texas)
StatusRecruiting
StartedApril 7, 2026
Main results expectedApril 1, 2033
Study endsApril 1, 2033
Registry record updatedJuly 30, 2026
Trial IDNCT07737171 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with pancreatic pre-malignant lesions or pancreatic cancer who are undergoing EUS-RFA at the hosting center and can provide informed consent and complete follow-up.

Probably not a fit

Patients whose pancreatic lesions do not respond to EUS-RFA or who have contraindications to follow-up may not experience benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a 7-year prospective registry at a single center that follows patients who are undergoing EUS-guided radiofrequency ablation for pancreatic lesions. It aims to document safety and efficacy outcomes in real-world practice. The study collects data on patients with pancreatic pre-malignant lesions or pancreatic cancer who are treated with EUS-RFA and are able to complete follow-up.

Why it matters

Potential benefit: If successful, the registry may clarify safety profiles and potential benefits of EUS-RFA for pancreatic lesions, guiding clinical decisions.

How similar studies have gone: Previous studies using EUS-RFA in pancreatic lesions have shown feasibility; this registry will add real-world safety and effectiveness data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosis of any pancreatic pre-malignant lesion and/or pancreatic malignancy
* Patients already undergoing EUS-RFA for treatment of pancreatic lesions clinically

Exclusion Criteria:

* Patients with co-existing malignancies of other organs (or a prior history of such)
* Patients unable to provide informed consent
* Patients unable to complete follow-up

Where it's running

  • The University of Texas Health Science Center at Houston
    Houston, Texas, United States
    Recruiting

Study contacts

  • Principal investigator: Nirav Thosani, MD — The University of Texas Health Science Center at Houston (UTHealth Houston)
  • Study coordinator: Amatullah Alibhai, MBA
  • Email: Amatullah.Alibhai@uth.tmc.edu
  • Phone: 713-500-6658

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.