Clinical trial Recruiting at 1 site Interventional Ages 21 and up

Erector spinae versus lateral transversus abdominis plane block for pain after open appendectomy

Official title: Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial

Run by Cairo University · NCT07351253 · Data updated 2026-11-12

This study will test whether an erector spinae plane block or a lateral TAP block gives better pain relief for adults having open appendectomy.

More Postoperative Analgesia trials

Quick facts

Study typeInterventional
Ages21 Years and up
SexAll
Enrollment68 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Cairo, Cairo Governorate)
StatusRecruiting
StartedJanuary 25, 2026
Main results expectedMay 2026
Study endsMay 2026
Registry record updatedMarch 17, 2026
Trial IDNCT07351253 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults scheduled for open appendectomy who can use the numeric rating scale, are not pregnant or lactating, have no coagulopathy or local infection, no allergy to study drugs, and have ASA physical status I–III are ideal candidates.

Probably not a fit

People with chronic pain or regular opioid use, coagulopathy, local infection at the block site, allergy to the study drugs, ASA status above III, or who are pregnant or lactating are unlikely to be eligible or to benefit from the procedures tested.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults undergoing open appendectomy are randomly assigned to receive either an erector spinae plane (ESP) block or a lateral transversus abdominis plane (TAP) block after induction of general anesthesia. Intraoperative inadequate analgesia is treated with fentanyl boluses if heart rate or systolic blood pressure rise by 20% from baseline. Postoperative pain management includes scheduled paracetamol and diclofenac, with intravenous morphine titration given if the numeric rating scale (NRS) exceeds 3. Outcomes focus on analgesic effect and opioid requirements after surgery.

Why it matters

Potential benefit: If successful, the better block could reduce postoperative pain and opioid use after open appendectomy.

How similar studies have gone: Both ESP and TAP blocks have been shown in prior studies to reduce postoperative pain for abdominal surgery, though direct head-to-head comparisons for open appendectomy are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* adult patients, undergoing open appendectomy.

Exclusion Criteria:

* American society of anesthesiologist-physical status \>III,
* allergy to any of the study drugs,
* coagulopathy
* local infection,
* history of chronic pain or regular opioid use;
* inability to comprehend the Numeric Rating Scale (NRS),
* pregnant or lactating women.

Where it's running

  • Cairo University
    Cairo, Cairo Governorate, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.