Erector spinae versus lateral transversus abdominis plane block for pain after open appendectomy
Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial
This study will test whether an erector spinae plane block or a lateral TAP block gives better pain relief for adults having open appendectomy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 68 (estimated) |
| Ages | 21 Years and up |
| Sex | All |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Trial ID | NCT07351253 on ClinicalTrials.gov |
What this trial studies
Adults undergoing open appendectomy are randomly assigned to receive either an erector spinae plane (ESP) block or a lateral transversus abdominis plane (TAP) block after induction of general anesthesia. Intraoperative inadequate analgesia is treated with fentanyl boluses if heart rate or systolic blood pressure rise by 20% from baseline. Postoperative pain management includes scheduled paracetamol and diclofenac, with intravenous morphine titration given if the numeric rating scale (NRS) exceeds 3. Outcomes focus on analgesic effect and opioid requirements after surgery.
Who should consider this trial
Good fit: Adults scheduled for open appendectomy who can use the numeric rating scale, are not pregnant or lactating, have no coagulopathy or local infection, no allergy to study drugs, and have ASA physical status I–III are ideal candidates.
Not a fit: People with chronic pain or regular opioid use, coagulopathy, local infection at the block site, allergy to the study drugs, ASA status above III, or who are pregnant or lactating are unlikely to be eligible or to benefit from the procedures tested.
Why it matters
Potential benefit: If successful, the better block could reduce postoperative pain and opioid use after open appendectomy.
How similar studies have performed: Both ESP and TAP blocks have been shown in prior studies to reduce postoperative pain for abdominal surgery, though direct head-to-head comparisons for open appendectomy are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients, undergoing open appendectomy. Exclusion Criteria: * American society of anesthesiologist-physical status \>III, * allergy to any of the study drugs, * coagulopathy * local infection, * history of chronic pain or regular opioid use; * inability to comprehend the Numeric Rating Scale (NRS), * pregnant or lactating women.
Where this trial is running
Cairo, Cairo Governorate
- Cairo University — Cairo, Cairo Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: Maha Mostafa, MD
- Email: maha.mostafa@cu.edu.eg
- Phone: +201000365115
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.