Erector spinae versus lateral transversus abdominis plane block for pain after open appendectomy
Official title: Analgeisc Effect of Erector Spinae Plane Block Versus Lateral Transversus Abdominis Plane Block in Patients Undergoing Open Abendectomy Surgery: a Randomized Controlled Trial
Run by Cairo University · NCT07351253 · Data updated 2026-11-12
This study will test whether an erector spinae plane block or a lateral TAP block gives better pain relief for adults having open appendectomy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 68 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Status | Recruiting |
| Started | January 25, 2026 |
| Main results expected | May 2026 |
| Study ends | May 2026 |
| Registry record updated | March 17, 2026 |
| Trial ID | NCT07351253 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for open appendectomy who can use the numeric rating scale, are not pregnant or lactating, have no coagulopathy or local infection, no allergy to study drugs, and have ASA physical status I–III are ideal candidates.
✕Probably not a fit
People with chronic pain or regular opioid use, coagulopathy, local infection at the block site, allergy to the study drugs, ASA status above III, or who are pregnant or lactating are unlikely to be eligible or to benefit from the procedures tested.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing open appendectomy are randomly assigned to receive either an erector spinae plane (ESP) block or a lateral transversus abdominis plane (TAP) block after induction of general anesthesia. Intraoperative inadequate analgesia is treated with fentanyl boluses if heart rate or systolic blood pressure rise by 20% from baseline. Postoperative pain management includes scheduled paracetamol and diclofenac, with intravenous morphine titration given if the numeric rating scale (NRS) exceeds 3. Outcomes focus on analgesic effect and opioid requirements after surgery.
Why it matters
Potential benefit: If successful, the better block could reduce postoperative pain and opioid use after open appendectomy.
How similar studies have gone: Both ESP and TAP blocks have been shown in prior studies to reduce postoperative pain for abdominal surgery, though direct head-to-head comparisons for open appendectomy are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients, undergoing open appendectomy. Exclusion Criteria: * American society of anesthesiologist-physical status \>III, * allergy to any of the study drugs, * coagulopathy * local infection, * history of chronic pain or regular opioid use; * inability to comprehend the Numeric Rating Scale (NRS), * pregnant or lactating women.
Where it's running
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Cairo University
Cairo, Cairo Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Maha Mostafa, MD
- Email: maha.mostafa@cu.edu.eg
- Phone: +201000365115
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.