Erector spinae plane block versus serratus anterior plus PECS II for pain control after breast‑conserving surgery
Comparison of Analgesic Efficacy and Opioid Consumption of Erector Spinae Plane Block Versus Serratus Anterior Block With Additional Pecto-Intercostal II Block in Breast-Conserving Surgery
This study will test if an erector spinae plane block or a combined serratus anterior plus PECS II block gives better pain relief and reduces opioid use in adults having breast‑conserving cancer surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | Female |
| Sponsor | Kayseri City Hospital Government |
| Locations | 1 site (Kayseri, Kocasinan) |
| Trial ID | NCT07368413 on ClinicalTrials.gov |
What this trial studies
In a prospective randomized trial at Kayseri City Hospital, 70 adults (ASA I–III, 18–75 years) undergoing breast‑conserving cancer surgery will be assigned to receive either an ultrasound‑guided erector spinae plane block (ESPB) or a combined serratus anterior plane block with PECS II (SAPB + PECS II) before general anesthesia. All blocks will be performed preoperatively by the same experienced anesthesiologist and checked with a pinprick test. Patients will have surgery under general anesthesia and postoperative morphine patient‑controlled analgesia, with pain scores and total opioid consumption recorded. Outcomes will compare intraoperative analgesia and postoperative opioid use between groups using standard statistical methods (p < 0.05 considered significant).
Who should consider this trial
Good fit: Adults aged 18–75 with ASA physical status I–III undergoing breast‑conserving surgery, without bleeding or coagulation disorders or neuropathy, and with preoperative breast pain NRS < 4 are ideal candidates.
Not a fit: Patients with systemic or regional infection, known allergy to local anesthetics, coagulation disorders, neuropathy, or those unwilling to participate are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, the better block technique could lower postoperative pain and reduce opioid requirements after breast‑conserving surgery.
How similar studies have performed: Previous smaller randomized trials and observational studies suggest ESPB, SAPB, and PECS II can reduce postoperative pain and opioid use, but direct head‑to‑head comparisons are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 75 years * ASA physical status I-III * No history of bleeding or coagulation disorders * Absence of neuropathy * Preoperative breast region NRS score \< 4 Exclusion Criteria: * systemic or regional infection * known allergy to local anesthetics * Unwillingness to participate in the study
Where this trial is running
Kayseri, Kocasinan
- Kasyeri City Hospital — Kayseri, Kocasinan, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Çiğdem Ünal Kantekin, Associate Professor of Medicin — Kayseri City Hospital
- Study coordinator: Erdoğan Rahmi Çinçin, Resident Doctor
- Email: erdo.cincin@gmail.com
- Phone: +90538 862 31 08
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.