Endoscopic treatment for biliary strictures after liver transplantation
Endoscopic Management of Non-anastomotic Biliary Strictures Following Liver Transplantation. Registry of the Italian Society of Digestive Endoscopy.
This study tests if using special tubes called biliary stents can help improve liver function in patients who develop bile duct blockages after a liver transplant.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Fondazione Policlinico Universitario Agostino Gemelli IRCCS Academic / other |
| Locations | 1 site (Roma, RM) |
| Trial ID | NCT05761483 on ClinicalTrials.gov |
What this trial studies
This study evaluates the outcomes of endoscopic management using ERCP for patients with non-anastomotic biliary strictures that occur following liver transplantation. It focuses on patients diagnosed with these strictures through direct cholangiogram or MRCP, particularly those affecting the hepatic hilum. The study aims to assess the effectiveness of biliary stents in improving liver function tests in this patient population.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with diagnosed non-anastomotic biliary strictures affecting the hepatic hilum.
Not a fit: Patients who have previously undergone endoscopic or percutaneous treatments or those with altered anatomy due to prior surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve liver function and quality of life for patients suffering from biliary strictures after liver transplantation.
How similar studies have performed: Other studies have shown promising results with endoscopic management of biliary strictures, suggesting this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 * Non anastomotic biliary strictures diagnosed by direct cholangiogram (T-tube) or MRCP * Stricture involving the hepatic hilum until secondary branches * Increase of liver function tests * Signature of the informed consent Exclusion Criteria: * Previopus endoscopic or percutaneous treatments * Patient candidate to metal stents placement * Previous surgery resulting in altered anatomy
Where this trial is running
Roma, RM
- Fondazione Policlinico Gemelli IRCCS — Roma, Rm, Italy (Recruiting)
Study contacts
- Principal investigator: Andrea Tringali, MD, PhD — Fondazione Policlinico Gemelli IRCCS, Rome, Italy
- Study coordinator: Andrea Tringali, MD, PD
- Email: andrea.tringali@unicatt.it
- Phone: +393287372601
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.