Endoscopic surgery for early-stage nasopharyngeal cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the use of endoscopic nasopharyngectomy as a treatment for patients with newly diagnosed Stage I nasopharyngeal carcinoma. The approach aims to improve surgical outcomes by minimizing complications associated with traditional open surgery, leveraging advancements in endoscopic techniques. Patients will receive endoscopic surgery combined with intensity-modulated radiotherapy, which is designed to enhance treatment efficacy while reducing adverse effects. The study focuses on patients who have not received prior treatment and meet specific health criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Previously untreated, biopsy-proven World Health Organization (WHO) types II or III NPC; Stage I disease (American Joint Committee on Cancer 7th edition); Between 18 and 70 years old; Adequate bone marrow, liver and renal function; Satisfactory performance status: a score of 0 or 1 using the Eastern Cooperative Oncology Group System; Patients provided signed informed consent.

Exclusion Criteria:

* Evidence of relapse or distant metastasis; History of prior malignancy or previous treatment for NPC; The presence of uncontrolled life-threatening diseases; The investigator considered the patient unable to complete the study.

Where it's running

• Sun Yat-sen University Cancer Center
  Guangzhou, Guangdong, China Recruiting
• The First Affiliated Hospital, Sun Yat-Sen University
  Guangzhou, Guangdong, China Recruiting
• The First People's Hospital of Foshan
  Guangzhou, Guangdong, China Recruiting
• Zhongshan People's Hospital
  Zhongshan, Guangdong, China Recruiting
• The People's Hospital of Guangxi Zhuang Autonomous Region
  Nanning, Guangxi, China Recruiting

Study contacts

• Study coordinator: Ming-Yuan Chen, MD,Ph.D
• Email: chmingy@mail.sysu.edu.cn
• Phone: 86-13903052650

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.