Embolization treatment for meningioma

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of endovascular embolization as a treatment for meningioma, a type of brain tumor that often requires intervention when it grows or causes symptoms. The approach aims to reduce intraoperative bleeding and improve clinical outcomes for patients undergoing treatment. By assessing both radiological and clinical results, the study seeks to expand treatment options for patients with meningioma, particularly in cases where traditional surgery or radiotherapy may not be ideal. The study includes patients diagnosed with typical intracranial meningioma who meet specific eligibility criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Radiological diagnose of typical intracranial meningioma (homogenous contrast enhancement or dural attachment)
* Indication for treatment due to growth, symptoms or both
* Tumor location suggestive of vascular supply via middle meningeal artery branches
* Age 18 years or older
* Karnofsky performance status of 90 or better (able to carry on normal activity and work)

Exclusion Criteria:

* Informed consent not possible (e.g. language barriers, aphasia, cognitive impaired)
* Previously treated for meningioma
* Intraosseous growth
* Tumor related brain edema
* Neurofibromatosis type 2
* Systemic cancer
* Epilepsy
* Progressive neurodegenerative disorder (eg. MS, Parkinsons disease)
* History of psychiatric disorder
* Unfit for participation for any other reason judged by the physician including patients
* Contraindications to MRI
* Allergic to contrast agents
* Relative contraindications to endovascular treatment judged from CT angiography (tortoise carotid arteries, carotid stenosis, calcified aortic arch, anatomical vascular variants/anomalies suggesting increased risk with endovascular treatment)
* DSA (Digital subtraction angiography) from carotid artery suggesting that significant vascular supply is from other vessels than the MMA.

Where it's running

• St Olavs Hospital
  Trondheim, Norway Recruiting

Study contacts

• Principal investigator: Ole Solheim, PhD — St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
• Study coordinator: Ole Solheim, PhD
• Email: ole.solheim@ntnu.no
• Phone: +4772575256

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Combination therapy with IN10018 and dalpiciclib for progressive meningioma

  This phase 1 study tests whether taking IN10018 with dalpiciclib is safe and tolerable in adults with growing meningiomas to see if the combo can help control the tumor.

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• JZP3507 (ONC206) for recurrent Grade 2/3 meningioma

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• Panitumumab-IRDye800 for guiding brain tumor surgery

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  Recruiting Early Phase 1 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07493447

• Zanzalintinib for recurrent or progressive meningioma

  This trial tests whether zanzalintinib can help people whose meningioma has come back or kept growing after standard treatments.

  Recruiting at 20 sites Phase 2 Exelixis · Birmingham, Alabama and 19 other locations · NCT07428616

• Meningioma: How social factors and personal risks relate to health outcomes

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• Skin closure after brain tumor surgery: running absorbable versus interrupted non-absorbable sutures

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  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT07413796

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.