Electrophysiologic effects of 360° capsular release for frozen shoulder
Official title: Electrophysiological Evidence of Neural Function Improvement After Extended Arthroscopic Circumferential Capsular Release for Adhesive Capsulitis
Run by Acibadem University · NCT07495306 · Data updated 2026-11-12
We will test whether arthroscopic 360° capsular release causes measurable changes in axillary and musculocutaneous nerve function in adults (21–70) with frozen shoulder who haven't improved with conservative care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years to 70 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Acibadem University Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Status | Recruiting |
| Started | February 26, 2026 |
| Main results expected | February 26, 2027 |
| Study ends | March 14, 2027 |
| Registry record updated | March 27, 2026 |
| Trial ID | NCT07495306 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 21–70 with adhesive capsulitis who have not improved with conservative treatments and are scheduled for arthroscopic 360° capsular release and can provide informed consent for EMG testing.
✕Probably not a fit
Patients with known peripheral neuropathy, prior brachial plexus or ipsilateral neurovascular surgery, active infection, coagulation disorders, or pregnancy are excluded and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-center observational study enrolls adults aged 21–70 with adhesive capsulitis who are scheduled for arthroscopic 360° capsular release. Participants undergo baseline and follow-up electromyography (EMG) and nerve conduction studies to detect morphological and functional changes in the axillary and musculocutaneous nerves after inferior capsular release and peri-coracoid dissection. Surgical technique and perioperative findings will be recorded and correlated with electrophysiological data. The study aims to quantify the frequency, pattern, and clinical relevance of any nerve alterations associated with circumferential capsular release.
Why it matters
Potential benefit: If successful, the results could clarify nerve risk during 360° capsular release and help surgeons refine techniques to reduce the chance of nerve injury.
How similar studies have gone: Neurological complications after shoulder arthroscopy are reported as rare, and prior data on electrophysiological effects of circumferential capsular release are limited, so this represents a relatively novel prospective evaluation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 21 and 70 years * Diagnosis of adhesive capsulitis (frozen shoulder) * Persistent symptoms despite conservative treatment (e.g., physical therapy, medication, or intra-articular injections) * Planned arthroscopic capsular release surgery * Ability to provide informed consent Exclusion Criteria: * Known peripheral neuropathy * Previous brachial plexus injury * History of ipsilateral shoulder neurovascular surgery * Previous proximal brachial plexus surgery * Coagulation disorders * Active infection * Pregnancy
Where it's running
-
Acibadem Mehmet Ali Aydinlar University Hospital
Istanbul, Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Nezih Ziroglu, MD — Acibadem University
- Study coordinator: Nezih Ziroglu, MD
- Email: nezih.ziroglu@yahoo.com
- Phone: +90 505 631 6484
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Spinal and Kaltenborn mobilization for a stiff shoulder (frozen shoulder)
A randomized trial tests spinal mobilization with arm movement and Kaltenborn mobilization to see if they reduce pain and improve motion and function in people with adhesive capsulitis.
-
Shoulder Frozen Shoulder: TAME vs Corticosteroid Injection
This study tests whether transcatheter arterial microembolization (TAME) works better than corticosteroid injections for people with frozen shoulder.
-
Comparing different NSAIDs plus home exercises for frozen shoulder
This will test whether taking one of several NSAIDs (diclofenac, meloxicam, or indomethacin) together with home shoulder exercises helps adults aged 18–75 with frozen shoulder and whether pain type changes the benefit.
-
Ultrasound-guided shoulder injections for frozen shoulder
This tests whether adding ultrasound-guided suprascapular nerve block, with or without a subacromial injection, to a home exercise program reduces pain and improves shoulder function in adults with chronic frozen shoulder.
-
Treatment for Frozen Shoulder using Corticosteroid Injection and Nerve Block
This study is testing whether a combination of a corticosteroid injection and a nerve block can help people with Frozen Shoulder feel less pain and move their shoulder better compared to a fake treatment.
-
Evaluating physical therapy and steroid injections for frozen shoulder treatment
This study is testing whether combining physical therapy with steroid injections helps people with frozen shoulder feel better compared to just getting steroid injections and waiting to see what happens.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.