Electroacupuncture to prevent menstrual-related migraine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the safety and potential benefit of electroacupuncture for reducing migraine days in people with menstrually related migraine. Participants receive either real electroacupuncture or sham electroacupuncture in a controlled setting. The trial uses a headache diary to confirm diagnosis and track changes in headache frequency and duration. It is conducted at a single center in Beijing, China, led by Guang’anmen Hospital. The goal is to determine if the treatment has an effect beyond placebo, while monitoring safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. meet the diagnostic criteria for MRM according to the ICHD-3, with a documented history of MRM for at least 12 months;
2. have a confirmed diagnosis of migraine by a neurologist;
3. aged 18-45 years;
4. have regular menstrual cycles (28 ± 7 days) with menstruation lasting 3-7 days;
5. have experienced ≥3 headache days during each menstrual cycle (days -2 to +3) and ≥5 total headache days per cycle over the past 3 months and baseline period; migraine attacks must last 4-72 hours without acute medication, or at least 2 hours when treated;
6. have completed a headache diary during the screening period (covering at least one full menstrual cycle), demonstrating good compliance;
7. headache diary data during screening period must meet the ICHD-3 criteria for MRM and fulfill criteria (4) and (5);
8. voluntarily sign the informed consent.

Exclusion Criteria:

1. irregular menstrual cycles, defined as cycle length outside the range of 28±7 days or menstruation duration \<3 days or \>7 days;
2. presence of secondary headache disorders, facial neuralgia, or cranial neuralgia;
3. combined with serious primary diseases such as cardiovascular, hepatic, renal, gastrointestinal, or hematological disorders that may interfere with the treatment protocol, or comorbid neurological conditions such as epilepsy, parkinson's disease, or other central nervous system disorders;
4. headache symptoms caused by other conditions, such as moderate to severe head or neck trauma, perimenstrual infections, intracranial tumors, intracranial infections, endocrine or metabolic disorders;
5. receipt of preventive treatment for headache within 1 month prior to the screening visit;
6. afraid of needles or received acupuncture treatment within 3 months;
7. unwillingness to undergo the study intervention or failure to sign the informed consent.

Where it's running

• Department of Acupuncture, China Academy of Chinese Medical Sciences Guang'anmen Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Weiming Wang, Ph.D — Guang'anmen Hospital of China Academy of Chinese Medical Sciences
• Study coordinator: Weiming Wang, Ph.D
• Email: wangweiming1a1@163.com
• Phone: +8613426424993

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.