ELATE: Endovascular thrombectomy in extended time windows for large-vessel stroke
Official title: Evaluation of Clinical Outcomes Following Endovascular Thrombectomy for Acute Ischemic Stroke With Anterior Large Vessel Occlusion in Extended Time Window (24-72 Hours)
Run by 115 People's Hospital · NCT07922317 · Data updated 2026-11-12
This study tests whether performing endovascular thrombectomy 24 to 72 hours after stroke onset helps people with large-vessel stroke compared to medical treatment alone.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 284 (estimated) |
| Sponsor | 115 People's Hospital Government |
| Locations | 1 site (Ho Chi Minh City, Vietnam) |
| Status | Recruiting |
| Started | July 6, 2026 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2028 |
| Registry record updated | November 6, 2026 |
| Trial ID | NCT07922317 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 and older with AIS due to anterior circulation LVO, presenting 24–72 hours after onset or last known well, with NIHSS ≥ 8 (or progression to ≥ 8), and imaging indicating salvageable tissue per perfusion or ASPECTS criteria.
✕Probably not a fit
Patients with intracranial hemorrhage, unfavorable imaging criteria, or lacking salvageable brain tissue are less likely to benefit from EVT in this late window.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
ELATE is a prospective observational study comparing clinical outcomes and safety of endovascular thrombectomy against best medical therapy in adults with acute ischemic stroke due to anterior large vessel occlusion who present 24 to 72 hours after onset or last known well. Eligible patients have substantial neurological deficit and imaging signs suggesting salvageable brain tissue, using CT/MR perfusion or ASPECTS criteria. The study focuses on real-world practice, including settings with limited access to advanced imaging, to assess feasibility and outcomes of extending the time window for EVT. Intervention is endovascular treatment, and outcomes will be observed and analyzed in relation to baseline imaging and clinical status. Ethical consent is required per local regulations.
Why it matters
Potential benefit: If successful, the approach could expand the window for EVT and improve outcomes for select patients with anterior circulation LVO who present late.
How similar studies have gone: Prior trials demonstrated benefit of EVT within 6–24 hours using advanced imaging; extension beyond 24 hours remains less established, making this observational evidence important but exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Presentation with acute ischemic stroke within 24 to 72 hours of stroke onset or last known well. * Baseline NIHSS ≥ 8 (If patients have NIHSS \< 8 at admission and experienced END to an NIHSS score ≥ 8 or higher, they also were included if they were 24 to 72 hours from the LKW at this point) * Clinical diagnosis of AIS due to anterior circulation LVO (internal carotid artery (ICA) extracranial or intracranial segment, middle cerebral artery (MCA) M1 and proximal M2 segment) on brain imaging (CTA/MRA). * Imaging criteria: must fulfill at least one: * 1\) Core-penumbra mismatch on CT perfusion (CTP) or MR perfusion (MRP) assessed: infarct core volume ≤ 70mL, mismatch ratio ≥ 1,8 and mismatch volume ≥ 15mL. * 2\) ASPECTS ≥6 on non-contrast CT or diffusion-weighted imaging (DWI). * Written informed consent (by patient or proxy, according to local requirements) Exclusion Criteria: * Intracranial hemorrhage identified by CT or MRI * Pre-stroke modified Rankin Score (mRS) score of \>2 (indicating previous disability) * Any terminal illness such that the patient has a life expectance of less than 1 year. * Patients with active cancer and undergoing treatment for cancer are excluded * Pregnancy
Where it's running
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115 People'S Hospital
Ho Chi Minh City, Vietnam, Vietnam Recruiting
Study contacts
- Study coordinator: Hang Tran, M.D
- Email: minhhangtran93@gmail.com
- Phone: +84778771795
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Intra-arterial Alteplase after successful reperfusion following mechanical thrombectomy
This trial tests whether giving a small amount of alteplase directly into the artery after a successful thrombectomy helps adults with acute ischemic stroke recover better.
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Minimally invasive surgery to remove deep (basal ganglia) brain hemorrhages
This observational study will see if minimally invasive surgery helps adults aged 18–80 with spontaneous deep (basal ganglia) intracerebral hemorrhage who present within 72 hours, compared with standard medical care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.