Effects of statins and exercise on health markers in people with high cholesterol
Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With Dyslipidaemia
This study tests if taking a cholesterol-lowering medication along with a structured exercise program can improve health markers in people aged 40-65 with high cholesterol.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 40 Years to 65 Years |
| Sex | All |
| Sponsor | University of the Faroe Islands Academic / other |
| Locations | 1 site (Tórshavn) |
| Trial ID | NCT06841536 on ClinicalTrials.gov |
What this trial studies
This study investigates how the combination of atorvastatin, a statin medication, and a structured exercise program influences health markers in individuals with dyslipidemia. It aims to understand the molecular effects of statins on muscle cell energy centers (mitochondria) and overall fitness. Participants aged 40-65 with elevated LDL cholesterol levels will be enrolled, and their responses to the intervention will be closely monitored through protein analysis and fitness assessments.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 40-65 with LDL cholesterol levels greater than 4.0 mmol/L.
Not a fit: Patients with serious chronic diseases, a history of cardiovascular disease, or those who engage in regular high-intensity exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the management of dyslipidemia by optimizing the benefits of statin therapy alongside exercise.
How similar studies have performed: While the combination of statins and exercise has been explored, this specific approach focusing on molecular effects is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age: 40-65 years * LDL-C \> 4.0 mmol/L. Exclusion Criteria: * Diagnosed with serious chronic disease including type 1 or 2 diabetes. * Cancer. * A history of atherosclerotic cardiovascular disease. * A history of major depression or other severe psychiatric disorders. * Severe renal dysfunction (creatinine clearance \<30 mL/min). * Severe hepatic impairment. * Active pregnancy or breast feeding. * Active cigarette or e-cigarette smoker. * Regular (\>2 hours pr week) aerobic high-intensity exercise training.
Where this trial is running
Tórshavn
- University of the Faroe Islands — Tórshavn, Faroe Islands (Recruiting)
Study contacts
- Study coordinator: Tórur Sjúrðarson, PhD
- Email: torurs@setur.fo
- Phone: +298 292251
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.