Effects of SGLT2 inhibitors on heart health in type 2 diabetes patients after heart attacks
Official title: Real World Observation of SGLT2 Inhibitors on Clinical Outcomes and Left Ventricular Remodeling in Type 2 Diabetic Patients with Acute Myocardial Infarction, a Prospective, Multi-center Registry Study
Run by Seoul St. Mary's Hospital · NCT05770687 · Data updated 2026-11-12
This study is testing if a diabetes medication called SGLT2 inhibitors can help improve heart health and reduce heart problems in people with type 2 diabetes who have had a heart attack.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 19 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Seoul St. Mary's Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | August 1, 2020 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | January 3, 2025 |
| Trial ID | NCT05770687 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include type 2 diabetes patients who have recently suffered an acute myocardial infarction and are starting SGLT2 inhibitors.
✕Probably not a fit
Patients with type 1 diabetes, those using insulin or GLP-1 analogues, or previous users of SGLT2 inhibitors may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the impact of SGLT2 inhibitors on clinical outcomes and left ventricular remodeling in type 2 diabetes patients who have experienced an acute myocardial infarction and undergone percutaneous coronary intervention. Conducted across eight hospitals in South Korea, the study will compare outcomes in patients using SGLT2 inhibitors to a control group from a previous cohort. The hypothesis is that SGLT2 inhibitors will lead to reduced cardiovascular events and improved heart function post-myocardial infarction.
Why it matters
Potential benefit: If successful, this study could provide insights into optimal diabetes management strategies that improve heart health after heart attacks.
How similar studies have gone: While previous studies have shown benefits of SGLT2 inhibitors in diabetes patients without cardiovascular disease, this specific approach in acute myocardial infarction patients is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Acute myocardial infarction who were treated with percutaneous coronary intervention * Type 2 diabetes mellitus * Started SGLT2 inhibitors \<1 month before/after PCI Exclusion Criteria: * Type 1 diabetes mellitus * Insulin / GLP-1 analogue users * Previous users of SGLT2 inhibitors * Pregnancy
Where it's running
-
Seoul St. Mary's Hospital
Seoul, South Korea Recruiting
Study contacts
- Principal investigator: Kiyuk Chang, MD, PhD — Seoul St. Mary's Hospital
- Study coordinator: Kiyuk Chang, MD, PhD
- Email: kiyuk@catholic.ac.kr
- Phone: 82-2-2258-1139
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.