Effects of Propofol vs. Sevoflurane Anesthesia on Brain Tumor Surgery Outcomes
Official title: Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Craniotomy for Primary Brain Tumors
Run by Kaohsiung Medical University Chung-Ho Memorial Hospital · NCT05141877 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests whether using propofol or sevoflurane anesthesia during brain tumor surgery helps patients recover better and live longer.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 706 (estimated) |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital Academic / other |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung) |
| Trial ID | NCT05141877 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 20 to 80 years who are classified as ASA class I-III and are scheduled for elective craniotomy for primary brain tumors.
✕Probably not a fit
Patients with severe mental disorders, poor liver function, or those undergoing emergency surgery or treatment for recurrent tumors are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of two different anesthesia methods, propofol and sevoflurane, on patients undergoing elective craniotomy for primary brain tumors. Patients are randomly assigned to receive either propofol or sevoflurane, with careful monitoring of various parameters such as vital signs, intraoperative blood loss, and postoperative complications. The study aims to evaluate the impact of these anesthetic agents on patient recovery and overall survival rates over a period of three years.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthesia protocols that enhance recovery and survival rates for brain tumor patients.
How similar studies have gone: Previous studies have shown varying success with different anesthetic approaches in surgical outcomes, but this specific comparison of propofol and sevoflurane in brain tumor surgeries is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Twenty to eighty-year-old. 2. ASA class I-III. 3. Patients undergoing elective craniotomy for primary brain tumors under general anesthesia. Exclusion Criteria: 1. Severe mental disorder 2. Poor liver function 3. Pregnant or lactating women 4. Morbidly obese 5. Allergy to any of the drugs used in this study 6. Recurrent tumor or repeat surgery 7. Biopsy cases 8. Incomplete outcome-data 9. Palliative treatment after surgery 10. simultaneous treatment of other malignancies 11. Emergency surgery 12. Presence of other malignant tumors 13. Combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine 14. Diagnosed as benign brain tumor 15. cerebellum tumor and pituitary gland tumor.
Where it's running
-
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan Recruiting
Study contacts
- Principal investigator: Zhi-Fu Wu — Kaohsiung Medical University
- Study coordinator: Zhi-Fu Wu, MD
- Email: aneswu@gmail.com
- Phone: 07-3121101
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions
A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.
-
Maintenance radiotherapy after standard glioblastoma treatment
This study tests whether a single 2 Gy maintenance radiotherapy dose after standard treatment is safe and feasible for adults with newly diagnosed glioblastoma.
-
BCB-276 CAR T therapy for DIPG in children and young adults
This study tests BCB-276, a patient's own CAR T cells against DIPG, after standard radiation, to see if it is safe and can help extend survival.
-
Temozolomide safety and effectiveness in adults with Grade III–IV glioma
This study tests how safe and effective Amitzo temozolomide is in adults with Grade III or IV glioma in Iran, without a control group.
-
Home-based vision training guided by brain imaging
This study tests whether at‑home, image-guided visual training can improve visual field function for adults with stroke-related vision loss.
-
Memantine and raloxifene to protect memory after brain radiation
This study tests whether adding memantine and raloxifene to brain radiation can help adults preserve memory better than radiation alone.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.