Effects of Propofol vs. Sevoflurane Anesthesia on Brain Tumor Surgery Outcomes
Impact of Propofol-Based Total Intravenous Anesthesia Versus Anesthesia With Sevoflurane on Long-term Outcomes With Patients Undergoing Elective Craniotomy for Primary Brain Tumors
PHASE4 · Kaohsiung Medical University Chung-Ho Memorial Hospital · NCT05141877
This study tests whether using propofol or sevoflurane anesthesia during brain tumor surgery helps patients recover better and live longer.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 706 (estimated) |
| Ages | 20 Years to 80 Years |
| Sex | All |
| Sponsor | Kaohsiung Medical University Chung-Ho Memorial Hospital (other) |
| Drugs / interventions | chemotherapy, radiation |
| Locations | 1 site (Kaohsiung) |
| Trial ID | NCT05141877 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of two different anesthesia methods, propofol and sevoflurane, on patients undergoing elective craniotomy for primary brain tumors. Patients are randomly assigned to receive either propofol or sevoflurane, with careful monitoring of various parameters such as vital signs, intraoperative blood loss, and postoperative complications. The study aims to evaluate the impact of these anesthetic agents on patient recovery and overall survival rates over a period of three years.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 20 to 80 years who are classified as ASA class I-III and are scheduled for elective craniotomy for primary brain tumors.
Not a fit: Patients with severe mental disorders, poor liver function, or those undergoing emergency surgery or treatment for recurrent tumors are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved anesthesia protocols that enhance recovery and survival rates for brain tumor patients.
How similar studies have performed: Previous studies have shown varying success with different anesthetic approaches in surgical outcomes, but this specific comparison of propofol and sevoflurane in brain tumor surgeries is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Twenty to eighty-year-old. 2. ASA class I-III. 3. Patients undergoing elective craniotomy for primary brain tumors under general anesthesia. Exclusion Criteria: 1. Severe mental disorder 2. Poor liver function 3. Pregnant or lactating women 4. Morbidly obese 5. Allergy to any of the drugs used in this study 6. Recurrent tumor or repeat surgery 7. Biopsy cases 8. Incomplete outcome-data 9. Palliative treatment after surgery 10. simultaneous treatment of other malignancies 11. Emergency surgery 12. Presence of other malignant tumors 13. Combined propofol and inhalation anesthesia or other anesthetics, such as ketamine or dexmedetomidine 14. Diagnosed as benign brain tumor 15. cerebellum tumor and pituitary gland tumor.
Where this trial is running
Kaohsiung
- Kaohsiung Medical University Chung-Ho Memorial Hospital — Kaohsiung, Taiwan (RECRUITING)
Study contacts
- Principal investigator: Zhi-Fu Wu — Kaohsiung Medical University
- Study coordinator: Zhi-Fu Wu, MD
- Email: aneswu@gmail.com
- Phone: 07-3121101
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Brain Tumor, Primary brain tumor, Propofol, Sevoflurane, Survival