Effects of Propofol on Brain Connectivity in Glioma Patients
Effects of Propofol on Auditory Event-related Potentials and Brain Functional Connectivity in Patients With Supratentorial Glioma
This study tests how different levels of sedation with Propofol affect brain activity in patients with brain tumors to help improve anesthesia care for them.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Beijing Tiantan Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05352685 on ClinicalTrials.gov |
What this trial studies
This study investigates how different sedation depths with Propofol affect brain network connectivity and auditory event-related potentials in patients with supratentorial gliomas. Using electroencephalogram (EEG) and auditory event-related potential (AERP) methods, the research aims to better understand the sedation depth in glioma patients, which is often challenging to monitor accurately. The findings could lead to improved anesthesia practices tailored specifically for this patient population.
Who should consider this trial
Good fit: Ideal candidates are Chinese-speaking adults aged 18-60 with a diagnosis of supratentorial glioma and ASA physical status I-II.
Not a fit: Patients with significant airway issues, obesity, hearing impairments, or other neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance anesthesia management for glioma patients, leading to safer surgical outcomes.
How similar studies have performed: While there is ongoing research into anesthesia depth monitoring, this specific approach focusing on glioma patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18 - 60 years old; 2. American Society of Anesthesiologists (ASA) physical status rating I-II; 3. Supratentorial glioma (frontal, temporal, parietal, insular ；WHO grade I-III); 4. Native Chinese speaker; 5. Signed informed consent. Exclusion Criteria: 1. Mallampati airway class≥III; 2. BMI\>30kg/m2; 3. Combined OSAS or Stop-BANG score≥3; 4. Hearing impairment 5. Combined epilepsy symptoms 6. Recurrent or multiple intracranial tumors 7. Concomitant other psychiatric or neurological disorders 8. Pregnancy and lactation
Where this trial is running
Beijing, Beijing
- Beijing Tiantan Hospital, Capital Medical University — Beijing, Beijing, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.