Effects of PD-L1 on Pain After Lung Cancer Surgery

The Effects of Programmed Death-ligand 1 on Postoperative Pain for Lung Cancer Patients

This study is testing how levels of a protein called PD-L1 in lung cancer patients can affect their pain after surgery to see if it can help improve pain management.

Quick facts

• Study type: Observational
• Enrollment: 100 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: Peking University People's Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT06503432 on ClinicalTrials.gov

What this trial studies

This observational study investigates the relationship between plasma programmed death-ligand 1 (PD-L1) levels and postoperative pain in lung cancer patients undergoing video-assisted thoracoscopic surgery (VATS). Patients will be categorized based on their PD-L1 expression levels, and differences in both acute and chronic postoperative pain will be analyzed between the high and low PD-L1 groups. The goal is to understand how PD-L1 levels influence pain outcomes and to potentially tailor pain management strategies based on individual genetic profiles.

Who should consider this trial

Good fit: Ideal candidates are lung cancer patients aged 18-80 who are scheduled for video-assisted thoracoscopic surgery.

Not a fit: Patients with a history of opioid abuse or known psychiatric disorders may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved pain management strategies for lung cancer patients after surgery.

How similar studies have performed: While the relationship between PD-L1 and pain management is being explored, this specific approach is relatively novel and has not been extensively tested in similar studies.

Eligibility criteria

Inclusion Criteria:

1. American Society of Anesthesiologists physical status I-IV (males and females).
2. 18-80 years of age.
3. Patients undergoing video-assisted thoracoscopic surgery for malignant lung disease.

Exclusion Criteria:

1. History of opioid abuse.
2. Known psychiatric disorders.
3. Unexpected conversion to thoracotomy or transferred to intensive care unit for further treatment.
4. Combined with other surgeries or sites.

Where this trial is running

Beijing, Beijing Municipality

• Peking University People's Hospital — Beijing, Beijing Municipality, China (Recruiting)

Study contacts

• Principal investigator: Xue Tian, MD — Peking University People's Hospital
• Study coordinator: Xue Tian, MD

Conditions Lung Cancer; Postoperative Pain