Effects of pain and pain relief on nerve excitability
The Effects of Pain and Pain Relief on Peripheral Nerve Excitability
This study looks at how pain and pain relief affect nerve activity and other body responses in people experiencing discomfort.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University of Aarhus Academic / other |
| Locations | 1 site (Aarhus N) |
| Trial ID | NCT06356376 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how pain and subsequent pain relief influence the excitability of peripheral C-fibers and the autonomic nervous system. Participants will undergo thermal stimulation while their nerve excitability, blood pressure, heart rate, respiration rate, gastric motility, and sympathetic skin response are continuously monitored. The goal is to understand the physiological changes that occur during pain and relief, providing insights into pain management.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals who can provide informed consent and do not have chronic pain or major diseases.
Not a fit: Patients with chronic pain conditions or those on pain medication within the last 24 hours may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of pain mechanisms and improve pain management strategies.
How similar studies have performed: While similar studies have explored pain mechanisms, this specific approach using microneurography and continuous monitoring is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy Participants able to give informed consent. Exclusion Criteria: * Chronic pain conditions * Neurological or Psychiatric disease * Other major diseases * Pain medication within the last 24 hours
Where this trial is running
Aarhus N
- Danish Pain Research Center — Aarhus N, Denmark (Recruiting)
Study contacts
- Study coordinator: Alexander G Kristensen, MD, PhD
- Email: alexgramm@clin.au.dk
- Phone: +45 93 52 28 64
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.