Effects of omega-3 fish oil on recovery after surgery for advanced gastric cancer
Effects of Omega-3 Fish Oil Fat Emulsion on Rehabilitation and Immune Function After Radical Surgery Combined With Intraperitoneal Hyperthermic Infusion Chemotherapy in Patients With Locally Advanced Gastric Cancer
This study tests if taking omega-3 fish oil can help people recover better after surgery for advanced gastric cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | The Affiliated Hospital of Qingdao University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Qingdao, Shan Dong) |
| Trial ID | NCT06047158 on ClinicalTrials.gov |
What this trial studies
This study investigates how omega-3 fish oil fat emulsion impacts immune function and recovery in patients undergoing radical surgery combined with intraperitoneal hyperthermic infusion chemotherapy for locally advanced gastric cancer. It aims to evaluate changes in immune markers, complications, length of hospital stay, and overall costs associated with hospitalization. Participants will have their baseline data collected and analyzed to determine the efficacy of the omega-3 intervention using statistical software.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 75 with locally advanced gastric cancer who meet specific staging criteria and have no prior history of gastric surgery or other malignancies.
Not a fit: Patients who have undergone prior chemotherapy or radiotherapy, or those with contraindications to surgery, may not benefit from this study.
Why it matters
Potential benefit: If successful, this could enhance recovery and immune function in patients after surgery, potentially reducing complications and healthcare costs.
How similar studies have performed: While the use of omega-3 fatty acids in cancer care is explored, this specific approach combining it with hyperthermic chemotherapy is relatively novel and not extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The age is 18 to 75 years old. * For advanced gastric cancer, according to the TNM staging specified by the 8th edition AJCC, the clinical staging or EUS staging is above T2. There is no distant metastasis before operation, and the tumor does not directly invade the surrounding organs (liver, pancreas, spleen and transverse mesocolon, etc.). * There is no obvious contraindication to surgery. * The preoperative physical status score of Eastern American Cancer Cooperation (ECOG) was 0 or 1. * The preoperative ASA grade was grade Ⅰ-Ⅲ. * No previous history of gastric surgery, no history of other malignant tumors. * After explaining the nature and purpose of the study, agree to sign an informed consent form, give voluntary consent to participate in the study, and comply with the requirements of the study. Exclusion Criteria: * Radiotherapy or chemotherapy before operation. * Use of immunosuppressants such as hormones within 3 months before treatment. * Preoperative anemia (hemoglobin \< 90g/L) and severe hypoalbuminemia (albumin \< 30g/L). * With severe heart and lung and other important organ dysfunction. * More serious metabolic and immune diseases, such as hyperthyroidism, poor blood glucose control in diabetes, obesity, hyperlipidemia (triglyceride \> 3mmol/L, total bile solid \> 6.2mmol/L). * Severe infection before operation. * With complete intestinal obstruction, intestinal perforation and intestinal necrosis. * During the operation, it was found that radical operation could not be performed or combined organ resection was needed. * Operation time \> 6 hours, intraoperative bleeding \> 400ml
Where this trial is running
Qingdao, Shan Dong
- Ruiqing Liu — Qingdao, Shan Dong, China (Recruiting)
Study contacts
- Study coordinator: Liu Ruiqing, Doctor
- Email: liuruiqing@smail.nju.edu.cn
- Phone: 18661809036
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.