Effects of Nicotinamide Riboside on Cognition and Sleep in Older Adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the impact of nicotinamide riboside (NR) supplementation on cognitive function and sleep quality in older adults. It aims to determine whether increasing levels of nicotinamide adenine dinucleotide (NAD+) through NR can enhance brain-derived neurotrophic factor (BDNF) expression, which is crucial for cognitive health. Participants will be assessed using both subjective and objective measures of sleep and cognition, with a focus on those experiencing cognitive impairment and poor sleep quality. The study will also explore the relationship between NR supplementation and serum BDNF levels.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score \>5

Exclusion Criteria:

* Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20

Where it's running

• Buffalo Veteran Affairs Medical Center
  Buffalo, New York, United States Recruiting
• State University of New York at Buffalo
  Buffalo, New York, United States Not yet recruiting
• University at Buffalo State University of New York
  Buffalo, New York, United States Not yet recruiting

Study contacts

• Study coordinator: Carleara Weiss, PhD, MS, RN
• Email: carleara@buffalo.edu
• Phone: 7168282006

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.