Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Effects of natural light on stroke recovery complications

Official title: The Effects of Naturalistic Light on Post Stroke Complications Related Brain Areas in Stroke Patients During Admission for Rehabilitation

Run by Copenhagen University Hospital, Rigshospitalet · NCT06922409 · Data updated 2026-11-12

This study tests if using natural light during rehab can help stroke patients feel less depressed and tired as they recover.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment45 (estimated)
SponsorCopenhagen University Hospital, Rigshospitalet
Academic / other
Locations1 site (Glostrup Municipality, Capital Region)
StatusRecruiting
StartedApril 10, 2025
Main results expectedApril 1, 2026
Study endsJanuary 1, 2030
Registry record updatedApril 15, 2025
Trial IDNCT06922409 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are stroke patients experiencing moderate to severe fatigue and/or depression who are admitted for rehabilitation.

Probably not a fit

Patients with severe cognitive impairments, such as those unable to communicate or cooperate, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how exposure to naturalistic light can influence post-stroke complications such as depression and fatigue in patients undergoing rehabilitation. By utilizing artificial light that mimics the spectrum and rhythm of sunlight, the researchers aim to assess its impact on mental states and circadian regulation. The effects will be measured through questionnaires, MRI scans, and biological markers related to inflammation and sleep. The study focuses on stroke patients who require at least 10 days of rehabilitation.

Why it matters

Potential benefit: If successful, this approach could significantly improve the mental health and recovery outcomes for stroke patients.

How similar studies have gone: Previous studies have indicated positive outcomes with light therapy in similar contexts, suggesting potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients scoring moderate-severe fatigue and/or depression OR NO fatigue and/or depressione which are evaluated as candidates for the rehabilitation unit.

Exclusion Criteria:

* GCS \< 15
* No functioning nervus opticus or retina in both eyes
* Unable to open both eyes
* Non communicating patients e.g. severe aphasia (incompetent patients)
* Unable to cooperate to the physical examinations
* Less than 10 days of hospitalization in the rehabilitation department
* Claustrophobia
* If the sub investigator finds the study participant unfit to conduct the investigations

Where it's running

  • Faculty of Health and Medical Sciences - University of Copenhagen
    Glostrup Municipality, Capital Region, Denmark
    Recruiting

Study contacts

  • Principal investigator: Anders Sode West, MD, PhD — Glostrup University Hospital, Copenhagen
  • Study coordinator: Anders Sode West, MD, PhD.
  • Email: anders.sode.west@regionh.dk
  • Phone: +4538634051

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Building physical capacity after chronic stroke

    This 12-week modified cardiac rehabilitation program will try to improve physical fitness and mood in people living with chronic stroke, including those with post-stroke depression.

    Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07039305

  • Deep phenotyping to explore recovery in young adults after stroke

    This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

    Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

  • Stem cell therapy for chronic stroke recovery

    This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

    Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

  • AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

    This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

    Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

  • Web-based therapy using action observation and mirror therapy for arm weakness after stroke

    This trial tests whether a mobile telerehabilitation app delivering action observation therapy (AOT) alone or combined AOT with mirror therapy (AOT-MT) can improve upper limb function in people with subacute stroke.

    Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT07921108

  • Remote Ischaemic Conditioning for Fatigue After Stroke 2

    Aat least 12 weeks after stroke, adults with post-stroke fatigue will try a simple hand-arm cuff treatment at home to see if it helps reduce fatigue.

    Recruiting Phase 2 Sheffield Teaching Hospitals NHS Foundation Trust · Sheffield, South Yorkshire · NCT07914647

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.