Effects of Mepivacaine on Neurological Symptoms After Stroke
Official title: Evaluation of the Efficacy and Safety of Mepivacaine on the Neurological Sequelae of Cerebral Infarction
Run by Assistance Publique - Hôpitaux de Paris · NCT05222828 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing if mepivacaine injections can help people who have had a stroke feel better by improving their neurological symptoms like movement issues and vision problems.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 38 (estimated) |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT05222828 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 to 85 who have experienced an ischemic stroke more than 30 days prior and exhibit specific neurological deficits.
✕Probably not a fit
Patients with hypersensitivity to local anesthetics, uncontrolled epilepsy, or those with certain severe comorbidities may not benefit from this treatment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of subcutaneous mepivacaine injections on chronic neurological symptoms in patients who have suffered an ischemic stroke. The study is based on a previous observation where a patient regained near-normal vision after receiving mepivacaine, suggesting potential benefits for other stroke-related deficits. Participants will be assessed for specific neurological impairments, including motor deficits, aphasia, and visual scotomas, to evaluate the treatment's efficacy. The trial aims to quantify improvements using reliable assessment scales.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the quality of life for patients with chronic neurological symptoms following a stroke.
How similar studies have gone: While this approach is novel, previous studies have shown promising results with similar interventions in small patient populations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Ischemic stroke more than 30 days old * Age between 18 and 85 years old * At least one deficit among: * motor deficit: score \< 56 on the Fugl-Meyer scale * aphasia: score ≥4 on the Aphasia Rapid Test, * presence of a clinically observable visual scotoma * Having given their written consent * Be affiliated with a social security scheme, Universal Medical Coverage (CMU) or any equivalent scheme Exclusion Criteria: * Hypersensitivity to amide-bonded local anesthetics. * Atrioventricular conduction disorders requiring permanent electro-systolic training not yet performed. * Epilepsy not controlled by treatment. * Porphyritic subjects. * Patients with a motor deficit (but no aphasia or scotomas) in whom there is spasticity leading to a major reduction in joint amplitude in passive motion * Minor patients, under curatorship or guardianship, under legal protection, deprived of liberty, pregnant or breastfeeding women * Pathologies involving the vital prognosis or compromising follow-up during the study period * Patient undergoing local amine anesthesia in the 7 days preceding V1. * Patients currently treated with no anti-arrhythmics such as tocainide, aprindine and mexiletine * Patients with a contraindication to MRI (ferro-magnetic surgical clips, eye implants, metallic foreign body intraocular or in the nervous system, implants or metallic objects likely to contain the radiofrequency field, cochlear implants, cerebral or cardiac pacemaker , implantable cardiac defibrillators) * Patients participating in research involving the therapeutic human person who may modify functional recovery (whether by medication or by medical device) or subject to an exclusion period for another research
Where it's running
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Hôpital Pitié Salpetrière
Paris, France Recruiting
Study contacts
- Study coordinator: COHEN Laurent, PUPH
- Email: laurent.cohen@aphp.fr
- Phone: 142161801
Similar studies
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This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.