Effects of low-intensity physical-cognitive exercise on cognitive function in older adults
Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia
This study is testing whether low-intensity exercise that combines physical activity and mental tasks can help older adults with mild cognitive impairment think better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 64 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | Chiang Mai University Academic / other |
| Locations | 1 site (Chiang Mai) |
| Trial ID | NCT06201533 on ClinicalTrials.gov |
What this trial studies
This study examines how low-intensity, combined physical-cognitive exercise impacts cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomly assigned to either an exercise group, which will engage in prescribed exercises three times a week for three months, or a control group that will maintain their usual lifestyle. The study aims to assess cognitive performance and biomarkers before and after the intervention, with the hypothesis that the exercise group will show significant improvements. The research seeks to identify the mechanisms through which this exercise protocol may enhance cognitive function.
Who should consider this trial
Good fit: Ideal candidates for this study are older adults diagnosed with mild cognitive impairment who are not currently taking cognitive medications.
Not a fit: Patients with medical conditions that make exercise unsafe or those who regularly engage in exercise may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological intervention to improve cognitive function in older adults with mild cognitive impairment.
How similar studies have performed: Previous studies have shown promising results for low-intensity exercise in enhancing cognitive function, suggesting that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * meeting the criteria for MCI (or mNCD) based on the recent DSM-V criteria * comprehend instructions and able to comply with the study procedures * not taking any medications for their cognition and not planning to start medications during the study trial Exclusion Criteria: * presence of medical condition(s) unsafe to exercise or affect cognition and mobility * presence of depressive symptoms * exercise regularly
Where this trial is running
Chiang Mai
- Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University — Chiang Mai, Thailand (Recruiting)
Study contacts
- Principal investigator: S Sungkarat, PhD — Chiang Mai University
- Study coordinator: S Kumfu
- Email: sirintip.ku@up.ac.th
- Phone: 6653949249
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.