Effects of low-intensity physical-cognitive exercise on cognitive function in older adults
Official title: Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia
Run by Chiang Mai University · NCT06201533 · Data updated 2026-11-12
This study is testing whether low-intensity exercise that combines physical activity and mental tasks can help older adults with mild cognitive impairment think better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 64 (estimated) |
| Sponsor | Chiang Mai University Academic / other |
| Locations | 1 site (Chiang Mai) |
| Status | Recruiting |
| Started | April 7, 2024 |
| Main results expected | January 25, 2026 |
| Study ends | March 2026 |
| Registry record updated | February 19, 2026 |
| Trial ID | NCT06201533 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are older adults diagnosed with mild cognitive impairment who are not currently taking cognitive medications.
✕Probably not a fit
Patients with medical conditions that make exercise unsafe or those who regularly engage in exercise may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study examines how low-intensity, combined physical-cognitive exercise impacts cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomly assigned to either an exercise group, which will engage in prescribed exercises three times a week for three months, or a control group that will maintain their usual lifestyle. The study aims to assess cognitive performance and biomarkers before and after the intervention, with the hypothesis that the exercise group will show significant improvements. The research seeks to identify the mechanisms through which this exercise protocol may enhance cognitive function.
Why it matters
Potential benefit: If successful, this study could provide a non-pharmacological intervention to improve cognitive function in older adults with mild cognitive impairment.
How similar studies have gone: Previous studies have shown promising results for low-intensity exercise in enhancing cognitive function, suggesting that this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * meeting the criteria for MCI (or mNCD) based on the recent DSM-V criteria * comprehend instructions and able to comply with the study procedures * not taking any medications for their cognition and not planning to start medications during the study trial Exclusion Criteria: * presence of medical condition(s) unsafe to exercise or affect cognition and mobility * presence of depressive symptoms * exercise regularly
Where it's running
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Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University
Chiang Mai, Thailand Recruiting
Study contacts
- Principal investigator: S Sungkarat, PhD — Chiang Mai University
- Study coordinator: S Kumfu
- Email: sirintip.ku@up.ac.th
- Phone: 6653949249
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.