Clinical trial Recruiting at 1 site Interventional Ages 60 and up

Effects of low-intensity physical-cognitive exercise on cognitive function in older adults

Official title: Effects of Low-intensity Exercise on Cognitive Function, Blood Biomarkers, and Metabolomic Alterations of Older Adults at Risk of Developing Dementia

Run by Chiang Mai University · NCT06201533 · Data updated 2026-11-12

This study is testing whether low-intensity exercise that combines physical activity and mental tasks can help older adults with mild cognitive impairment think better.

Quick facts

Study typeInterventional
Ages60 Years and up
SexAll
Enrollment64 (estimated)
SponsorChiang Mai University
Academic / other
Locations1 site (Chiang Mai)
StatusRecruiting
StartedApril 7, 2024
Main results expectedJanuary 25, 2026
Study endsMarch 2026
Registry record updatedFebruary 19, 2026
Trial IDNCT06201533 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are older adults diagnosed with mild cognitive impairment who are not currently taking cognitive medications.

Probably not a fit

Patients with medical conditions that make exercise unsafe or those who regularly engage in exercise may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how low-intensity, combined physical-cognitive exercise impacts cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomly assigned to either an exercise group, which will engage in prescribed exercises three times a week for three months, or a control group that will maintain their usual lifestyle. The study aims to assess cognitive performance and biomarkers before and after the intervention, with the hypothesis that the exercise group will show significant improvements. The research seeks to identify the mechanisms through which this exercise protocol may enhance cognitive function.

Why it matters

Potential benefit: If successful, this study could provide a non-pharmacological intervention to improve cognitive function in older adults with mild cognitive impairment.

How similar studies have gone: Previous studies have shown promising results for low-intensity exercise in enhancing cognitive function, suggesting that this approach may be effective.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* meeting the criteria for MCI (or mNCD) based on the recent DSM-V criteria
* comprehend instructions and able to comply with the study procedures
* not taking any medications for their cognition and not planning to start medications during the study trial

Exclusion Criteria:

* presence of medical condition(s) unsafe to exercise or affect cognition and mobility
* presence of depressive symptoms
* exercise regularly

Where it's running

  • Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University
    Chiang Mai, Thailand
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.