Effects of hydrogen-rich water on metabolic health in adults
The Effects of 12-week Hydrogen-rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults With Metabolic Syndrome and Varying Breath Hydrogen Levels
This study tests if drinking hydrogen-rich water every day can help adults with metabolic syndrome improve their body composition and metabolic health.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 30 Years to 65 Years |
| Sex | All |
| Sponsor | University of Novi Sad, Faculty of Sport and Physical Education Academic / other |
| Locations | 1 site (Novi Sad, Vojvodina) |
| Trial ID | NCT06968715 on ClinicalTrials.gov |
What this trial studies
The HYDRO-RESPOND trial is a 12-week randomized controlled study that investigates the impact of daily consumption of hydrogen-rich water on body composition and metabolic biomarkers in adults with metabolic syndrome. Participants are randomly assigned to receive either hydrogen-rich water or a placebo, and the study measures changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. Additionally, the trial examines how baseline breath hydrogen levels may affect individual responses to the treatment, aiming to identify predictors of effectiveness.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 30-65 years diagnosed with metabolic syndrome who are not physically active.
Not a fit: Patients with major chronic diseases, acute injuries, or those who have used metabolism-modulating pharmaceuticals recently may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel therapeutic approach to improve metabolic health in individuals with metabolic syndrome.
How similar studies have performed: While the concept of hydrogen-rich water is relatively novel, there have been limited studies exploring its effects, making this approach somewhat untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 30-65 years * Metabolic syndrome (NHS) (at least 3 of the 5 following criteria): * Waist circumference of ≥ 102 cm in men and ≥ 88 cm in women * Hypertriglyceridemia (≥ 1.695 mmol/L) * Low HDL-C (\< 1.04 mmol/dL in men and \< 1.30 mmol/dL in women) * High blood pressure (\> 130/85 mmHg) * High fasting glucose (\> 6.1 mmol/L) * Not physically active * Informed consent signed Exclusion Criteria: * Major chronic disease and acute injuries * History of dietary supplement use during the past 4 weeks * History of metabolism-modulating pharmaceuticals use during the past 4 weeks * No consent to randomization * Participation in other studies
Where this trial is running
Novi Sad, Vojvodina
- Applied Bioenergetics Lab at Faculty of Sport and PE — Novi Sad, Vojvodina, Serbia (Recruiting)
Study contacts
- Study coordinator: Sergej Ostojic, MD, PhD
- Email: sergej.ostojic@chess.edu.rs
- Phone: +38121450188
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.