Effects of gut bacteria on growth and immunity in children at high altitude
Characteristics of Intestinal Bacteria and Their Effects on Growth and Immune Function in Children at High Altitude in Diqing Tibetan Autonomous Prefecture, Yunnan Province
This study looks at how the gut bacteria of young children living at high altitudes affects their growth and immune health compared to children living at lower altitudes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 1 Year to 3 Years |
| Sex | All |
| Sponsor | Ruijin Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06157346 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how the gut microbiota of children living at high altitudes differs from those at lower altitudes, focusing on their growth, immune function, and metabolism. By collecting fecal samples and lifestyle questionnaires from children aged 1-3 years, researchers aim to understand the development and maturation of intestinal flora in plateau areas. The study compares these characteristics with children from low-altitude regions to analyze the impact of environmental factors on gut health. The ultimate goal is to provide insights that could enhance children's health in high-altitude regions.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 1-3 years living in high-altitude regions.
Not a fit: Patients who have taken probiotics or antibiotics within the last month or have significant underlying medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved health strategies for children living in high-altitude areas by understanding the role of gut microbiota.
How similar studies have performed: While studies on gut microbiota have been conducted, this specific focus on high-altitude children is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children aged 1-3 years old * Both men and women; * The child's legal guardian signed the informed consent to participate in the study. * The legal guardian of the child commits to follow the study procedures and cooperate with the entire study process Exclusion Criteria: * Probiotics or antibiotics within 1 month * Associated with clinically significant abnormalities in liver and kidney function, nervous system, respiratory system, and coagulation function as determined by the investigator * Unstable vital signs; * Have other underlying medical conditions * Individuals deemed unsuitable for this clinical trial.
Where this trial is running
Shanghai, Shanghai Municipality
- Ruijin Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Principal investigator: Chundi Xu — Ruijin Hospital
- Study coordinator: Xinqiong Wang
- Email: wxq11671@rjh.com.cn
- Phone: 0086-021-64370045
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.